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Volume 11, Issue 2, February 2019

Research Highlight

Sin1 – mTORC2 signaling drives glycolysis of developing thymocytes
Hongbo Chi*
J Mol Cell Biol, Volume 11, Issue 2, February 2019, 91-92, https://doi.org/10.1093/jmcb/mjy078
Abstract | Full Text 

Original Article

Metabolic regulation of T cell development by Sin1–mTORC2 is mediated by pyruvate kinase M2
Xinxing Ouyang , Yuheng Han , Guojun Qu, Man Li , Ningbo Wu , Hongzhi Liu, Omotooke Arojo, Hongxiang Sun, Xiaobo Liu, Dou Liu , Lei Chen , Qiang Zou , and Bing Su
J Mol Cell Biol, Volume 11, Issue 2, February 2019, 93-106, https://doi.org/10.1093/jmcb/mjy065
Abstract | Full Text 
ACBD3 is required for FAPP2 transferring glucosylceramide through maintaining the Golgi integrity Free
Jing Liao , Yuxiang Guan, Wei Chen , Can Shi , Dongdong Yao , Fengsong Wang, Sin Man Lam , Guanghou Shui , and Xinwang Cao
J Mol Cell Biol, Volume 11, Issue 2, February 2019, 107-117, https://doi.org/10.1093/jmcb/mjy030
Abstract | Full Text 
FTO is a transcriptional repressor to auto-regulate its own gene and potentially associated with homeostasis of body weight Free
Shu-Jing Liu , Hui-Ling Tang , Qian He , Ping Lu, Tao Fu , Xu-Ling Xu , Tao Su, Mei-Mei Gao, Shumin Duan , Yan Luo , and Yue-Sheng Long
J Mol Cell Biol, Volume 11, Issue 2, February 2019, 118-132, https://doi.org/10.1093/jmcb/mjy028
Abstract | Full Text 
The HDAC3 enzymatic activity regulates skeletal muscle fuel metabolism
Shiyang Song , Yefei Wen , Hui Tong , Emanuele Loro, Yingyun Gong, Jidong Liu , Sungguan Hong , Lei Li , Tejvir S. Khurana , Maoping Chu, and Zheng Sun
J Mol Cell Biol, Volume 11, Issue 2, February 2019, 133-143, https://doi.org/10.1093/jmcb/mjy066
Abstract | Full Text 
Interleukin-6 secretion is limited by self-signaling in endosomes
Danie¨lle R. J. Verboogen, Natalia H. Revelo , Martin ter Beest, and Geert van den Bogaart
J Mol Cell Biol, Volume 11, Issue 2, February 2019, 144-157, https://doi.org/10.1093/jmcb/mjy038
Abstract | Full Text 
Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3 Free
Qi Yang , Jielin Tang , Rongjuan Pei , XiaoXiao Gao , Jing Guo , Chonghui Xu , Yun Wang , Qian Wang , Chunchen Wu , Yuan Zhou , Xue Hu , He Zhao , Yanyi Wang , Xinwen Chen and Jizheng Chen
J Mol Cell Biol, Volume 11, Issue 2, February 2019, 158-169, https://doi.org/10.1093/jmcb/mjy035
Abstract | Full Text 
HITS-CLIP reveals sex-differential RNA binding and alterative splicing regulation of SRm160 in Drosophila Free
Chen Qiu, Yu Zhang , Yu-Jie Fan , Ting-Lin Pang , Yan Su , Shuai Zhan , and Yong-Zhen Xu
J Mol Cell Biol, Volume 11, Issue 2, February 2019, 170-181, https://doi.org/10.1093/jmcb/mjy029
Abstract | Full Text 

Letter to the Editor

Resident Prrx1 lineage stromal cells promote T cell survival in the spleen
Wanyao Zhang, Qian Yu, Huijuan Liu , and Baojie Li
J Mol Cell Biol, Volume 11, Issue 2, February 2019, 182-184, https://doi.org/10.1093/jmcb/mjy073
Abstract | Full Text 

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Cover: Glucose metabolism plays a key role in T cell development. CD4-CD8- double negative (DN) thymocytes, resided in the thymic cortex, are ‘baby’ T cells at the very beginning stage. With energy supplements, thymocytes at a later stage become ‘children’ T cells, receiving primary education in the thymic medulla. During this transition, mTORC2 signaling serves as the baby’s feeding bottle to promote DN thymocyte development and metabolism. See pages 93–106 by Ouyang et al. for details.