Volume 11, Issue 5, May 2019

Research Highlights

Nuclear actin switch of the INO80 remodeler
Jun Wu , Yimin Lao, and Bing Li
J Mol Cell Biol, Volume 11, Issue 5, May 2019, Pages 343-344, https://doi.org/10.1093/jmcb/mjy083
Abstract | Full Text 

Original Article

Structure and functional interactions of INO80 actin/Arp module
Xuan Zhang , Xuejuan Wang , Zhihui Zhang, and Gang Cai
J Mol Cell Biol, Volume 11, Issue 5, May 2019, Pages 345-355, https://doi.org/10.1093/jmcb/mjy062
Abstract | Full Text 
Muscle RING-finger protein-1 (MuRF1) functions and cellular localization are regulated by SUMO1 post-translational modification Free
Gabriel Heras , Arvind Venkat Namuduri , Leonardo Traini, Ganna Shevchenko, Alexander Falk, Sara Bergstro¨m Lind, Mi Jia, Geng Tian, and Stefano Gastaldello
J Mol Cell Biol, Volume 11, Issue 5, May 2019, Pages 356-370, https://doi.org/10.1093/jmcb/mjy036
Abstract | Full Text 
p53 upregulated by HIF-1α promotes hypoxia-induced G2/M arrest and renal fibrosis in vitro and in vivo Free
Limin Liu , Peng Zhang , Ming Bai , Lijie He , Lei Zhang , Ting Liu , Zhen Yang , Menglu Duan , Minna Liu , Baojian Liu, Rui Du , Qi Qian , and Shiren Sun
J Mol Cell Biol, Volume 11, Issue 5, May 2019, Pages 371-382,
Abstract | Full Text 
Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat Free
Yirong Zhang , Yawen Chen , Jianqun Zheng, Juan Wang, Shichao Duan, Wei Zhang, Xiumin Yan , and Xueliang Zhu
J Mol Cell Biol, Volume 11, Issue 5, May 2019, Pages 383-394, https://doi.org/10.1093/jmcb/mjy043
Abstract | Full Text 
IFN-stimulated P2Y13 protects mice from viral infection by suppressing the cAMP/EPAC1 signaling pathway Free
Chengfei Zhang, Yan Yan , Hongwang He, Li Wang, Na Zhang, Jie Zhang, Hongjun Huang, Nannan Wu, Hua Ren, Min Qian, Mingyao Liu, and Bing Du
J Mol Cell Biol, Volume 11, Issue 5, May 2019, Pages 395-407, https://doi.org/10.1093/jmcb/mjy045
Abstract | Full Text 
DICER1 regulates antibacterial function of epididymis by modulating transcription of β-defensins Free
Chunhua Tang, Minjie Ni, Shengsong Xie, Yao Zhang, Chaobao Zhang, Zimei Ni, Chen Chu, Ligang Wu, Yuchuan Zhou, and Yonglian Zhang
J Mol Cell Biol, Volume 11, Issue 5, May 2019, Pages 408-420, https://doi.org/10.1093/jmcb/mjy048
Abstract | Full Text 
SIN3B promotes integrin αV subunit gene transcription and cell migration of hepatocellular carcinoma Free
Qianqian Cai, Yuanyuan Liu, Ping Zhu, Chunlang Kang, Heyang Xu, Bing Qi, Rong Wang, Yiwei Dong, and Xing Zhong Wu
J Mol Cell Biol, Volume 11, Issue 5, May 2019, Pages 421-432, https://doi.org/10.1093/jmcb/mjy050
Abstract | Full Text 
Cover: Several large multi-subunit chromatin modifying or remodeling complexes contain nuclear actin and/or nuclear actinrelated proteins (Arps). Our structural analyses of INO80 complex and its actin/Arp module, combined with 3D reconstructions of different nucleosome binding states, illuminate that the highly mobile and flexible actin/Arp module serves a conformational switch controlling for nucleosome binding. See pages 345–355 by Zhang et al. for details.