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Volume 12, Issue 5, May 2020

Review

Regulatory networks between Polycomb complexes and non-coding RNAs in the central nervous system
Ya-Jie Xu, Pei-Pei Liu, Shyh-Chang Ng, Zhao-Qian Teng, Chang-Mei Liu
J Mol Cell Biol, Volume 12, Issue 5, May 2020, 327-336, https://doi.org/10.1093/jmcb/mjz114
Abstract | Full Text 

Articles

ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling
Pengcheng Ma, Ning-Ning Song, Xiaoning Cheng, Liang Zhu, Qiong Zhang, Long long Zhang, Xiangcai Yang, Huishan Wang, Qinghua Kong, Deli Shi, Yu-Qiang Ding, Bingyu Mao
J Mol Cell Biol, Volume 12, Issue 5, May 2020, 337-344, https://doi.org/10.1093/jmcb/mjz087
Abstract | Full Text 
NUMB enhances Notch signaling by repressing ubiquitination of NOTCH1 intracellular domain
Zhiyuan Luo, Lili Mu, Yue Zheng, Wenchen Shen, Jiali Li, Lichao Xu, Bo Zhong, Ying Liu, Yan Zhou
J Mol Cell Biol, Volume 12, Issue 5, May 2020, 345-358, https://doi.org/10.1093/jmcb/mjz088
Abstract | Full Text 
Isoform-specific involvement of Brpf1 in expansion of adult hematopoietic stem and progenitor cells
Qiuping He, Mengzhi Hong, Jincan He, Weixin Chen, Meng Zhao, Wei Zhao
J Mol Cell Biol, Volume 12, Issue 5, May 2020, 359-371, https://doi.org/10.1093/jmcb/mjz092
Abstract | Full Text 
Protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage
Liming Hong, Long Yan, Zhimin Xin, Jie Hao, Wenjing Liu, Shuyu Wang, Shujie Liao, Hongmei Wang, Xiaokui Yang
J Mol Cell Biol, Volume 12, Issue 5, May 2020, 372-385, https://doi.org/10.1093/jmcb/mjz105
Abstract | Full Text 
RUNX1-205, a novel splice variant of the human RUNX1 gene, has blockage effect on mesoderm–hemogenesis transition and promotion effect during the late stage of hematopoiesis
Wencui Sun, Jiahui Zeng, Jing Chang, Yuan Xue, Yonggang Zhang, Xu Pan, Ya Zhou, Mowen Lai, Guohui Bian, Qiongxiu Zhou, Jiaxing Liu, Bo Chen, Feng Ma
J Mol Cell Biol, Volume 12, Issue 5, May 2020, 386-396, https://doi.org/10.1093/jmcb/mjaa019
Abstract | Full Text 

Letter to the Editor

BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells
Jisha Antony, Gregory Gimenez, Terry Taylor, Umaima Khatoon, Robert Day, Ian M. Morison, Julia A. Horsfield
J Mol Cell Biol, Volume 12, Issue 5, May 2020, 397-399, https://doi.org/10.1093/jmcb/mjz114
Abstract | Full Text 

Research Advance

Comments on ‘In vitro culture of cynomolgus monkey embryos beyond early gastrulation’
Huaixiao Ma, Hongmei Wang, Ping Zheng, Lei Li
J Mol Cell Biol, Volume 12, Issue 5, May 2020, 400-402, https://doi.org/10.1093/jmcb/mjz108
Abstract | Full Text 

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Cover: Regulatory loop between Polycomb group (PcG) proteins and microRNAs (miRNAs) modulate multiple steps of neurogenesis and fate determination in the central nervous system development. Left: a well-characterized regulatory loop involving the PRC2-miR203-PRC1 circuit regulates neural stem cell (NSC) self-renewal and proliferation. Middle: miR-137 and miR-124 modulate neuronal differentiation by directly downregulating the expression of EZH2. Right: during synapse formation in developing neural circuits, miR-27b and miR-137 interact with PcG genes, thereby regulating local synaptic protein synthesis and shaping neural activity in rodent cortical networks. See pages 327-336 by Xu et al. for details.