Volume 12, Issue 9, September 2020

Perspective

Review

Gain-of-function mutant p53 in cancer progression and therapy
Cen Zhang, Juan Liu, Dandan Xu, Tianliang Zhang, Wenwei Hu, Zhaohui Feng
J Mol Cell Biol, Volume 12, Issue 9, September 2020, Pages 674-687, https://doi.org/10.1093/jmcb/mjaa040
Abstract | Full Text 

Articles

Deregulation of tumor suppressive ASXL1−PTEN/AKT axis in myeloid malignancies
Lei Cao, Xianyou Xia, Yu Kong, Fengqin Jia, Bo Yuan, Rui Li, Qian Li, YuxinWang, Mingrui Cui, Zhongye Dai, Huimin Zheng, Jesper Christensen, Yuan Zhou, Xudong Wu
J Mol Cell Biol, Volume 12, Issue 9, September 2020, Pages 688-699, https://doi.org/10.1093/jmcb/mjaa011
Abstract | Full Text 
Inhibition of tumor suppressor p73 by nerve growth factor receptor via chaperone-mediated autophagy
Daniel Nguyen, Kun Yang, Lucia Chiao, Yun Deng, Xiang Zhou, Zhen Zhang, Shelya X. Zeng, Hua Lu
J Mol Cell Biol, Volume 12, Issue 9, September 2020, Pages 700-712, https://doi.org/10.1093/jmcb/mjaa017
Abstract | Full Text 
MDMX phosphorylation-dependent p53 downregulation contributes to an immunosuppressive tumor microenvironment
Bing Wang, Chuan-Bian Lim, Jiawei Yan, Lizhen Li, Jufang Wang, John B. Little, Zhi-Min Yuan
J Mol Cell Biol, Volume 12, Issue 9, September 2020, Pages 713-722, https://doi.org/10.1093/jmcb/mjaa038
Abstract | Full Text 
Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling
Li Liu, Yudong Wu, Cheng Zhang, Chong Zhou, Yining Li, Yi Zeng, Chunbo Zhang, Rong Li, Daya Luo, Lieliang Wang, Long Zhang, Shuo Tu, Huan Deng, Shiwen Luo, Ye-Guang Chen, Xiangyang Xiong, Xiaohua Yan
J Mol Cell Biol, Volume 12, Issue 9, September 2020, Pages 723-737, https://doi.org/10.1093/jmcb/mjaa016
Abstract | Full Text 

Letters to the Editor

Abl1 deletion in gut stem cells suppresses p53 induction and promotes colitis-associated tumor formation 
Guo Yu, Jie Fu, Ana Romo, Baojie Li, Huijuan Liu
J Mol Cell Biol, Volume 12, Issue 9, September 2020, Pages 738-740, https://doi.org/10.1093/jmcb/mjaa022
Abstract | Full Text 
Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling
Chunxiao Zhang, Yan Liu, Yifang Zhang, Xiangxiang Wang, Tianlong Zhang, Jianping Ding
J Mol Cell Biol, Volume 12, Issue 9, September 2020, Pages 741-744, https://doi.org/10.1093/jmcb/mjaa025
Abstract | Full Text 

Research Advance

Cover: Granulocyte colony-stimulating factor (G-CSF) plays a critical role in adipocyte/cancer-associated adipocyte (CAA)–breast cancer interplay. Breast cancer cells are able to convert adipocytes into CAAs that exhibit altered gene transcription pattern. In particular, G-CSF, which is highly expressed and secreted by CAAs, activates Stat3 signaling in triple-negative breast cancer (TNBC) cells. The G-CSF/Stat3 signaling then drives TNBC cell malignant progression by promoting epithelial–mesenchymal transition (EMT) and invasion. The background shows G-CSF expression in the breast cancer tissue obtained from human breast cancer patients by immunohistochemistry analysis. See pages 723–737 by Liu et al. for details.