Volume 12, Issue 11, November 2020

Highlight

Perspective

Modern deep learning in bioinformatics
Haoyang Li, Shuye Tian, Yu Li, Qiming Fang, Renbo Tan, Yijie Pan, Chao Huang, Ying Xu, Xin Gao
J Mol Cell Biol, Volume 12, Issue 11, November 2020, Pages 823-827, https://doi.org/10.1093/jmcb/mjaa030
Abstract | Full Text 

Review

Toward precise CRISPR DNA fragment editing and predictable 3D genome engineering
Qiang Wu, Jia Shou
J Mol Cell Biol, Volume 12, Issue 11, November 2020, Pages 828-856, https://doi.org/10.1093/jmcb/mjaa060
Abstract | Full Text 

Articles

Landscape of genomic imprinting and its functions in the mouse mammary gland
Haibo Xu, Lina Zhao, Xu Feng, Yujie Ma, Wei Chen, Li Zou, Qin Yang, Jihong Sun, Hong Yu, Baowei Jiao
J Mol Cell Biol, Volume 12, Issue 11, November 2020, Pages 857-869, https://doi.org/10.1093/jmcb/mjaa020
Abstract | Full Text 
The protective role of m1A during stress-induced granulation
Marion Alriquet, Giulia Calloni, Adrı´an Martı´nez-Limo´n, Riccardo Delli Ponti, Gerd Hanspach, Martin Hengesbach, Gian G. Tartaglia, R. Martin Vabulas
J Mol Cell Biol, Volume 12, Issue 11, November 2020, Pages 870-880, https://doi.org/10.1093/jmcb/mjaa023
Abstract | Full Text 
Gene dysregulation analysis builds a mechanistic signature for prognosis and therapeutic benefit in colorectal cancer
Quanxue Li, Wentao Dai, Jixiang Liu, Qingqing Sang, Yi-Xue Li, Yuan-Yuan Li
J Mol Cell Biol, Volume 12, Issue 11, November 2020, Pages 881-893, https://doi.org/10.1093/jmcb/mjaa041
Abstract | Full Text 
RNF219 interacts with CCR4–NOT in regulating stem cell differentiation
Hao Du, Chen Chen, Yan Wang, Yang Yang, Zhuanzhuan Che, Xiaoxu Liu, Siyan Meng, Chenghao Guo, Manman Xu, Haitong Fang, Fengchao Wang, Chengqi Lin, Zhuojuan Luo
J Mol Cell Biol, Volume 12, Issue 11, November 2020, Pages 894-905, https://doi.org/10.1093/jmcb/mjaa061
Abstract | Full Text 

Letters to the Editor

Transcriptional output, cell-type densities, and normalization in spatial transcriptomics
Manuel Saiselet, Joe¨l Rodrigues-Vito´ria, Adrien Tourneur, Ligia Craciun, Alex Spinette, Denis Larsimont, Guy Andry, Joakim Lundeberg, Carine Maenhaut, Vincent Detours
J Mol Cell Biol, Volume 12, Issue 11, November 2020, Pages 906-908, https://doi.org/10.1093/jmcb/mjaa028
Abstract | Full Text 

Application Note

GNL-Scorer: a generalized model for predicting CRISPR on-target activity by machine learning and featurization
Jun Wang, Xi Xiang, Lars Bolund, Xiuqing Zhang, Lixin Cheng, Yonglun Luo
J Mol Cell Biol, Volume 12, Issue 11, November 2020, Pages 909-911, https://doi.org/10.1093/jmcb/mjz116
Abstract | Full Text 
Cover: Two different horses in the connected jade dragons represent ‘blessing in disguise’ ( , ), unifying ancient philosophy of multi-dimensions into a single theory. In this issue, Wu and Shou reviewed gene editing and synthetic biology, from transgene to gene targeting, from zinc-finger nuclease to CRISPR and focusing on the current understanding of the Cas9 systems, from blunt cleavage and random indels to staggered or cohesive cleavage and predictable editing, from single cutting to double cutting, and finally toward precise DNA fragment editing and 3D genome engineering. See pages 828–856 by Wu and Shou for details.