Volume 13, Issue 4, April 2021

Editorial

Orchestration of cell plasticity by phase separation
Xuebiao Yao
J Mol Cell Biol, Volume 13, Issue 4, April 2021, Pages 237-238, https://doi.org/10.1093/jmcb/mjab029
Abstract | Full Text 

Reviews

Mechanisms and regulation underlying membraneless organelle plasticity control
Hazrat Ismail, Xu Liu, Fengrui Yang, Junying Li, Ayesha Zahid, Zhen Dou, Xing Liu, Xuebiao Yao
J Mol Cell Biol, Volume 13, Issue 4, April 2021, Pages 239-258, https://doi.org/10.1093/jmcb/mjab028
Abstract | Full Text 
Membraneless organelles restructured and built by pandemic viruses: HIV-1 and SARS-CoV-2
Viviana Scoca, Francesca Di Nunzio
J Mol Cell Biol, Volume 13, Issue 4, April 2021, Pages 259-268, https://doi.org/10.1093/jmcb/mjab020
Abstract | Full Text 
Regulation of nonsense-mediated mRNA decay in neural development and disease
Paul Jongseo Lee, Suzhou Yang, Yu Sun, Junjie U. Guo
J Mol Cell Biol, Volume 13, Issue 4, April 2021, Pages 269-281, https://doi.org/10.1093/jmcb/mjab022
Abstract | Full Text 

Original Article

Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies Free
Maarten C. Hardenberg, Tessa Sinnige, Sam Casford, Samuel T. Dada, Chetan Poudel, Elizabeth A. Robinson, Monika Fuxreiter, Clemens F. Kaminksi, Gabriele S. Kaminski Schierle, Ellen A. A. Nollen, Christopher M. Dobson, Michele Vendruscolo
J Mol Cell Biol, Volume 13, Issue 4, April 2021, Pages 282-294, https://doi.org/10.1093/jmcb/mjaa075
Abstract | Full Text 
LncRNA Platr22 promotes super-enhancer activity and stem cell pluripotency
Pixi Yan, J. Yuyang Lu, Jing Niu, Juntao Gao, Michael Q. Zhang, Yafei Yin, Xiaohua Shen
J Mol Cell Biol, Volume 13, Issue 4, April 2021, Pages 295-313, https://doi.org/10.1093/jmcb/mjaa056
Abstract | Full Text 

Perspective

Phase separation, transcriptional elongation control, and human diseases
Chenghao Guo, Zhuojuan Luo, Chengqi Lin
J Mol Cell Biol, Volume 13, Issue 4, April 2021, Pages 314-318, https://doi.org/10.1093/jmcb/mjab023
Abstract | Full Text 

Letter to the Editor

Fluorescein-based monitoring of RNA N6-methyladenosine at single-nucleotide resolution
Xiao-Min Liu, Shen Wang, Xianqing Gan, Shu-Bing Qian, Jun Zhou
J Mol Cell Biol, Volume 13, Issue 4, April 2021, Pages 325-328, https://doi.org/10.1093/jmcb/mjaa057
Abstract | Full Text 
Cover: The cover shows that the lantern flickering on a boat gives signals to the city and two gates of the defensive wall open. During organelle remodeling, on the arrival of a boat (mitochondrion), flickering light from the lantern (permeability transition pore, PTP) gives strong signals to the city (nucleus), and two usually locked gates (H3K9me2 and H3K27me3) of the defensive wall respond and open immediately. Mitochondrial flicker, by short-term mPTP opening, acts as a retrograde signaling to specially open methylation gates of nucleus and facilitate somatic cell reprogramming process. See pages 747-751 by Liu et al. for details.