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Volume 13, Issue 4, April 2021

Editorial

Orchestration of cell plasticity by phase separation
Xuebiao Yao
J Mol Cell Biol, Volume 13, Issue 4, April 2021, 237-238, https://doi.org/10.1093/jmcb/mjab029
Abstract | Full Text 

Reviews

Mechanisms and regulation underlying membraneless organelle plasticity control
Hazrat Ismail, Xu Liu, Fengrui Yang, Junying Li, Ayesha Zahid, Zhen Dou, Xing Liu, Xuebiao Yao
J Mol Cell Biol, Volume 13, Issue 4, April 2021, 239-258, https://doi.org/10.1093/jmcb/mjab028
Abstract | Full Text 
Membraneless organelles restructured and built by pandemic viruses: HIV-1 and SARS-CoV-2
Viviana Scoca, Francesca Di Nunzio
J Mol Cell Biol, Volume 13, Issue 4, April 2021, 259-268, https://doi.org/10.1093/jmcb/mjab020
Abstract | Full Text 
Regulation of nonsense-mediated mRNA decay in neural development and disease
Paul Jongseo Lee, Suzhou Yang, Yu Sun, Junjie U. Guo
J Mol Cell Biol, Volume 13, Issue 4, April 2021, 269-281, https://doi.org/10.1093/jmcb/mjab022
Abstract | Full Text 

Original Article

Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies Free
Maarten C. Hardenberg, Tessa Sinnige, Sam Casford, Samuel T. Dada, Chetan Poudel, Elizabeth A. Robinson, Monika Fuxreiter, Clemens F. Kaminksi, Gabriele S. Kaminski Schierle, Ellen A. A. Nollen, Christopher M. Dobson, Michele Vendruscolo
J Mol Cell Biol, Volume 13, Issue 4, April 2021, 282-294, https://doi.org/10.1093/jmcb/mjaa075
Abstract | Full Text 
LncRNA Platr22 promotes super-enhancer activity and stem cell pluripotency
Pixi Yan, J. Yuyang Lu, Jing Niu, Juntao Gao, Michael Q. Zhang, Yafei Yin, Xiaohua Shen
J Mol Cell Biol, Volume 13, Issue 4, April 2021, 295-313, https://doi.org/10.1093/jmcb/mjaa056
Abstract | Full Text 

Perspective

Phase separation, transcriptional elongation control, and human diseases
Chenghao Guo, Zhuojuan Luo, Chengqi Lin
J Mol Cell Biol, Volume 13, Issue 4, April 2021, 314-318, https://doi.org/10.1093/jmcb/mjab023
Abstract | Full Text 
Membrane-associated phase separation: organization and function emerge from a two-dimensional milieu
Jonathon A. Ditlev
J Mol Cell Biol, Volume 13, Issue 4, April 2021, 319-324, https://doi.org/10.1093/jmcb/mjab010
Abstract | Full Text 

Letter to the Editor

Fluorescein-based monitoring of RNA N6-methyladenosine at single-nucleotide resolution
Xiao-Min Liu, Shen Wang, Xianqing Gan, Shu-Bing Qian, Jun Zhou
J Mol Cell Biol, Volume 13, Issue 4, April 2021, 325-328, https://doi.org/10.1093/jmcb/mjaa057
Abstract | Full Text 

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Cover: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rages during the winter, when the humidity and temperature are both low. The cardiovascular system can be severely affected after SARS-CoV-2 infection. The expression of angiotensin-converting enzyme 2 (ACE2) in the cardiovascular system predisposes it to SARS-CoV-2. In addition, cytokine storm caused by the overloaded inflammatory factors, including interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a), which are produced by the anti-virus response, may also contribute to the impairment of the cardiovascular system. See page 161–167 by Liu et al. for details.