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Volume 13, Issue 8, August 2021

Editorial

New discoveries in obesity and related metabolic diseases: from bench to bed
Weiping Jia
J Mol Cell Biol, Volume 13, Issue 8, August 2021, 541-542, https://doi.org/10.1093/jmcb/mjab063
Abstract | Full Text 

Articles

Knockdown of insulin-like growth factor 2 gene disrupts mitochondrial functions in the liv
Weiwei Gui, Yiyi Zhu, Shuiya Sun, Weifen Zhu, Bowen Tan, Hanxin Zhao, Chengxin Shang, Fenping Zheng, Xihua Lin, Hong Li
J Mol Cell Biol, Volume 13, Issue 8, August 2021, 543-555, https://doi.org/10.1093/jmcb/mjab030
Abstract | Full Text 
Benzo[a]pyrene stimulates miR-650 expression to promote the pathogenesis of fatty liver disease and hepatocellular carcinoma via SOCS3/JAK/STAT3 cascades
Yang Ge, Pengfei Gu, Wenbo Wang, Liyuan Cao, Lulu Zhang, Jingquan Li, Wei Mu, Hui Wang
J Mol Cell Biol, Volume 13, Issue 8, August 2021, 556-564, https://doi.org/10.1093/jmcb/mjab052
Abstract | Full Text 
Lipidomics reveals association of circulating lipids with body mass index and outcomes in IgA nephropathy patients
Yueyi Deng, Qingqing Wu, Wanjia Chen, Li Zhu, Wangyi Liu, Fangying Xia, Liang Sun, Xu Lin, Rong Zeng
J Mol Cell Biol, Volume 13, Issue 8, August 2021, 565-575, https://doi.org/10.1093/jmcb/mjab040
Abstract | Full Text 

Reviews

Multi-omics profiling: the way toward precision medicine in metabolic diseases
Cheng Hu, Weiping Jia
J Mol Cell Biol, Volume 13, Issue 8, August 2021, 576-593, https://doi.org/10.1093/jmcb/mjab051
Abstract | Full Text 
Metabolic surgery in China: present and future
Yinfang Tu, Yuqian Bao, Pin Zhang
J Mol Cell Biol, Volume 13, Issue 8, August 2021, 594-609, https://doi.org/10.1093/jmcb/mjab039
Abstract | Full Text 

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Cover: A model graph proposes the potential role of insulin-like growth factor 2 (IGF2) in regulating fatty liver. Knockdown of IGF2 (by siRNA) increases ROS production whereas decreases SIRT1 expression, which then causes a reduction of PGC1a levels in hepatocytes. As a result, mitochondrial biogenesis and ATP production are significantly inhibited, while mitochondrial fission is promoted. All these defects contribute to mitochondrial dysfunction and ultimately lead to fatty liver and obesity. See pages 543–555 by Gui et al. for details.