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Volume 13, Issue 11, November 2021

Reviews

Human neuromuscular junction three-dimensional organoid models and the insight in motor disorders
Kejing Zhang, Lei Bai, Wentao Xu, Chengyong Shen
J Mol Cell Biol, Volume 13, Issue 11, November 2021, 767-773, https://doi.org/10.1093/jmcb/mjab046
Abstract | Full Text 
Deciphering the PTM codes of the tumor suppressor p53
Jia Wen, Donglai Wang
J Mol Cell Biol, Volume 13, Issue 11, November 2021, 774-785, https://doi.org/10.1093/jmcb/mjab047
Abstract | Full Text 

Perspective

Autophagy in pancreatic cancer
Congting Guo, Ying Zhao
J Mol Cell Biol, Volume 13, Issue 11, November 2021, 786-790, https://doi.org/10.1093/jmcb/mjab053
Abstract | Full Text 

Articles

Capsaicin restores sodium iodine symporter-mediated radioiodine uptake through bypassing canonical TSH‒TSHR pathway in anaplastic thyroid carcinoma cells
Shichen Xu, Xian Cheng, Jing Wu, Yunping Wang, Xiaowen Wang, Liying Wu, Huixin Yu, Jiandong Bao, Li Zhang
J Mol Cell Biol, Volume 13, Issue 11, November 2021, 791-807, https://doi.org/10.1093/jmcb/mjab072
Abstract | Full Text 
Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner
Jin Zheng, Lun Suo, Yuxiao Zhou, Liling Jia, Jingwei Li, Yanping Kuang, Donghong Cui, Xuehong Zhang, Qiang Wu
J Mol Cell Biol, Volume 13, Issue 11, November 2021, 808-821, https://doi.org/10.1093/jmcb/mjab057
Abstract | Full Text 
Landscape dynamic network biomarker analysis reveals the tipping point of transcriptome reprogramming to prevent skin photodamage
Chengming Zhang, Hong Zhang, Jing Ge, Tingyan Mi, Xiao Cui, Fengjuan Tu, Xuelan Gu, Tao Zeng, Luonan Chen
J Mol Cell Biol, Volume 13, Issue 11, November 2021, 822-833, https://doi.org/10.1093/jmcb/mjab060
Abstract | Full Text 

Letters to the Editor

Syntelin inhibits triple-negative breast cancer cell proliferation and metastasis
McKay Mullen, Fengrui Yang, Jun Cao, Yang Cao, Xu Liu, Gee Young Lee, Tao Li, William Yao, Zhihong Yang, Jiahai Zhang, Kela Johnson, Felix Aikhionbare, Yong Chen, Xinjiao Gao, Dongmei Wang, Xia Ding, Hadiyah-Nicole Green, Xing Liu, Xuebiao Yao
J Mol Cell Biol, Volume 13, Issue 11, November 2021, 834-837, https://doi.org/10.1093/jmcb/mjab054
Abstract | Full Text 
MOCS2 links nucleotide metabolism to nucleoli function
Tamaki Suganuma, Selene K. Swanson, Madelaine Gogol, Timothy J. Garrett, Laurence Florens, Jerry L. Workman
J Mol Cell Biol, Volume 13, Issue 11, November 2021, 838-840, https://doi.org/10.1093/jmcb/mjab069
Abstract | Full Text 

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Cover: In anaplastic thyroid cancer, thyroid-stimulating hormone (TSH)-mediated activation of TSH receptor (TSHR) is impaired because of the aberrant silence of TSHR. Capsaicin, a transient receptor potential vanilloid type 1 (TRPV1) agonist, induces edifferentiation of the dedifferentiated anaplastic thyroid carcinoma cells through bypassing TSHR signal and augments radioiodine (RAI) therapeutic efficiency through increasing sodium iodine symporter expression and membrane trafficking. The butterflies represent the thyroid gland after effective RAI therapy for thyroid cancer. See pages 791–807 by Xu et al. for details.