Volume 14, Issue 9, September 2022

Editorial

Reviews

Surf4, cargo trafficking, lipid metabolism, and therapeutic implications
Yishi Shen, Hong-Mei Gu, Shucun Qin, Da-Wei Zhang
J Mol Cell Biol, Volume 14, Issue 9, September 2022, mjac063, https://doi.org/10.1093/jmcb/mjac063
Abstract | Full Text 
The role of O-GlcNAcylation in innate immunity and inflammation
Yongqiang Wang, Xiuwu Fang, Shuai Wang, Bin Wang, Feng Chu, Zhixin Tian, Long Zhang, Fangfang Zhou
J Mol Cell Biol, Volume 14, Issue 9, September 2022, mjac065, https://doi.org/10.1093/jmcb/mjac065
Abstract | Full Text 

Articles

SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade
Firdaus Samsudin, Palur Raghuvamsi, Ganna Petruk, Manoj Puthi, Jitka Petrlova, Paul MacAry, Ganesh S. Anand, Peter J. Bond, Artur Schmidtchen
J Mol Cell Biol, Volume 14, Issue 9, September 2022, mjac058, https://doi.org/10.1093/jmcb/mjac058
Abstract | Full Text 
Aberrant elevation of FTO levels promotes liver steatosis by decreasing the m6A methylation and increasing the stability of SREBF1 and ChREBP mRNAs 
Zhili Tang, Chao Sun, Ying Yan, Zhoumin Niu, Yuying Li, Xi Xu, Jing Zhang, Yuting Wu, Yan Li, Li Wang, Cheng Hu, Zhuoyang Li, Jingjing Jiang, Hao Ying
J Mol Cell Biol, Volume 14, Issue 9, September 2022, mjac061, https://doi.org/10.1093/jmcb/mjac061
Abstract | Full Text 
Developmental thyroid hormone action on pro-opiomelanocortin-expressing cells programs hypothalamic BMPR1A depletion and brown fat activation
Zhaofei Wu, M. Elena Martinez, Victoria DeMambro, Marie Francois, Arturo Hernandez
J Mol Cell Biol, Volume 14, Issue 9, September 2022, mjac078, https://doi.org/10.1093/jmcb/mjac078
Abstract | Full Text 
Cover: Proposed model for how SARS-CoV-2 spike protein boosts lipopolysaccharide (LPS)-mediated proinflammatory response. Spike protein disaggregates LPS micelles via binding to sites on the N-terminal domain, receptor-binding domain, and S2 subunit. Subsequently, LPS is transferred to its receptors, CD14 and the TLR4:MD-2 complex, which triggers proinflammatory reactions. Spike protein, therefore, acts as an intermediate in the LPS receptor transfer cascade. See mjac058 by Samsudin et al. for details.