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Volume 14, Issue 12, December 2022

Articles

scRNA-seq profiling of neonatal and adult thymus-derived CD4+ T cells by a T cell origin-time tracing model 
Yuheng Han, Xinxing Ouyang, Yao Chen, Shujing Lai, Hongxiang Sun, Ningbo Wu, Chun Ruan, Limin Lu, Bing Su
J Mol Cell Biol, Volume 14, Issue 12, December 2022, mjac072, https://doi.org/10.1093/jmcb/mjac072
Abstract | Full Text 
Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension
Jian Chen, Meiling Zhang, Yanjie Liu, Shihong Zhao, Yanxia Wang, Meng Wang, Wen Niu, Faguang Jin, Zhichao Li
J Mol Cell Biol, Volume 14, Issue 12, December 2022, mjac073, https://doi.org/10.1093/jmcb/mjac073
Abstract | Full Text 
Argon mitigates post-stroke neuroinflammation by regulating M1/M2 polarization and inhibiting NF-κB/NLRP3 inflammasome signaling 
Ke Xue, Mian Qi, Tongping She, Zhenglin Jiang, Yunfeng Zhang, Xueting Wang, Guohua Wang, Lihua Xu, Bin Peng, Jiayi Liu, Xinjian Song, Yuan Yuan, Xia Li
J Mol Cell Biol, Volume 14, Issue 12, December 2022, mjac077, https://doi.org/10.1093/jmcb/mjac077
Abstract | Full Text 
Circadian clock control of MRTF/SRF pathway suppresses beige adipocyte thermogenic recruitment
Xuekai Xiong, Weini Li, Ruya Liu, Pradip Saha, Vijay Yechoor, Ke Ma
J Mol Cell Biol, Volume 14, Issue 12, December 2022, mjac079, https://doi.org/10.1093/jmcb/mjac079
Abstract | Full Text 

Application Note

GoldenFish: a rapid and efficient system to customize constructs for zebrafish transgenesis
Zhanmei Jiang, Lirong Huang, Jieqiong Zhao, Yanfeng Li, Jianlong Ma, Rui Ni, Qifen Yang, Lingfei Luo, Yun Yang, Jingying Chen
J Mol Cell Biol, Volume 14, Issue 12, December 2022, mjac075, https://doi.org/10.1093/jmcb/mjac075
Abstract | Full Text 

Letter to the Editor

Targeted mutagenesis in rabbit using an engineered BhCas12b variant
Yingqi Jia, Tian Wang, Ding Zhao, Zhiquan Liu, Tingting Sui, Siyu Chen, Jinze Li, Liangxue Lai, Zhanjun Li
J Mol Cell Biol, Volume 14, Issue 12, December 2022, mjac076, https://doi.org/10.1093/jmcb/mjac076
Abstract | Full Text 

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Cover: In the mouse transient middle cerebral artery occlusion (tMCAO) model, microglia are activated and polarized toward the pro-inflammatory M1 phenotype after ischemia/reperfusion injury. Argon (Ar) treatment during ischemia suppresses microglial activation and shifts microglia from M1 to the anti-inflammatory M2 phenotype, consequently mitigating NLRP3 inflammasome-mediated neuroinflammation to attenuate brain injury (smaller infarct area depicted by dotted circle). This image was created with BioRender.com. See mjac077 by Xue et al. for details.