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Volume 15, Issue 2, February 2023

Research Highlight

Induction of membraneless organelles as a strategy for HIV-1 post-nuclear entry steps 
Sheng Zhou, Hongyu Deng
J Mol Cell Biol, Volume 15, Issue 2, February 2023, mjad013, https://doi.org/10.1093/jmcb/mjad013
Abstract | Full Text 

Articles

Tea domain transcription factor TEAD4 mitigates TGF-β signaling and hepatocellular carcinoma progression independently of YAP
Weicheng Luo, Yi Li, Yi Zeng, Yining Li, Minzhang Cheng, Cheng Zhang, Fei Li, Yiqing Wu, Chunhong Huang, Xiaolong Yang, Joachim Kremerskothen, Jianmin Zhang, Chunbo Zhang, Shuo Tu, Zhihua Li, Zhijun Luo, Zhenghong Lin, Xiaohua Yan
J Mol Cell Biol, Volume 15, Issue 2, February 2023, mjad010, https://doi.org/10.1093/jmcb/mjad010
Abstract | Full Text 
Transcription-wide impact by RESCUE-induced off-target single-nucleotide variants in mammalian cells 
Guo Li, Xiaoning Zhu, Yihan Wang, Hongru Ma, Yuzhe Wang, Hanyu Wu, Xiangyang Li, Yiling Wang, Jianen Gao, Xuexin Chen, Xingxu Huang, Yuan Yao, Xiaoxiang Hu
J Mol Cell Biol, Volume 15, Issue 2, February 2023, mjad011, https://doi.org/10.1093/jmcb/mjad011
Abstract | Full Text 
Degradation of helicase-like transcription factor (HLTF) by β-TrCP promotes hepatocarcinogenesis via activation of the p62/mTOR axis
Ye Tan, Di Wu, Ze-Yu Liu, Hong-Qiang Yu, Xiang-Ru Zheng, Xiao-Tong Lin, Ping Bie, Lei-Da Zhang, Chuan-Ming Xie
J Mol Cell Biol, Volume 15, Issue 2, February 2023, mjad012, https://doi.org/10.1093/jmcb/mjad012
Abstract | Full Text 
Exendin-4 attenuates atherosclerosis progression via controlling hematopoietic stem/progenitor cell proliferation
Cen Yan, Xiaojuan Ma, Sin Man Lam, Yuejie Zhang, Yu Cao, Yuan Dong, Li Su, Guanghou Shui, Yingmei Feng
J Mol Cell Biol, Volume 15, Issue 2, February 2023, mjad014, https://doi.org/10.1093/jmcb/mjad014
Abstract | Full Text 
hCINAP alleviates senescence by regulating MDM2 via p14ARF and
Xinping Huang, Yan Zhao, Min Wei, Ruipeng Zhuge, Xiaofeng Zheng
J Mol Cell Biol, Volume 15, Issue 2, February 2023, mjad015, https://doi.org/10.1093/jmcb/mjad015
Abstract | Full Text 

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Cover: Helicase-like transcription factor (HLTF), a tumour suppressor, is significantly downregulated in hepatocellular carcinoma (HCC) tissues. The elevated β-TrCP mediates HLTF polyubiquitination and degradation, which contributes to p62/mammalian target of rapamycin (mTOR) activation, leading to HCC proliferation and metastasis. Encouragingly, an inhibitor targeting mTOR effectively blocks β-TrCP-driven liver tumourigenesis, offering a promising therapeutic approach for treating HCC. See mjad012 by Tan et al. for details.