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Volume 2, Issue 2, April 2010

Research Highlights

Shifting in balance between osteogenesis and adipogenesis substantially influences hematopoiesis Free
Ryohichi Sugimura and Linheng Li
J Mol Cell Biol, Volume 2, Issue 2, April 2010, 61-62, https://doi.org/10.1093/jmcb/mjp030
Abstract | Full Text 
Type I and type II pathways of Fas-mediated apoptosis are differentially controlled by XIAP Free
Zhenyue Hao and Tak W. Mak
J Mol Cell Biol, Volume 2, Issue 2, April 2010, 63-64, https://doi.org/10.1093/jmcb/mjp034
Abstract | Full Text 
Sensorium: The Original Raison D'être of the Motile Cilium? Free
Lynne M. Quarmby and Michel R. Leroux
J Mol Cell Biol, Volume 2, Issue 2, April 2010, 65-67, https://doi.org/10.1093/jmcb/mjp036
Abstract | Full Text 
Live show of Rho GTPases in cell migration Free
Xiumin Yan, Yidong Shen, and Xueliang Zhu
J Mol Cell Biol, Volume 2, Issue 2, April 2010, 68-69, https://doi.org/10.1093/jmcb/mjp039
Abstract | Full Text 
Destruction of a destructor: a new avenue for cancer therapeutics targeting the Wnt pathway Free
Chunming Liu and Xi He
J Mol Cell Biol, Volume 2, Issue 2, April 2010, 70-73, https://doi.org/10.1093/jmcb/mjp040
Abstract | Full Text 
Neither too much nor too little: reactive oxygen species levels regulate Drosophila hematopoiesis Free
Alain Vincent and Michèle Crozatier
J Mol Cell Biol, Volume 2, Issue 2, April 2010, 74-75, https://doi.org/10.1093/jmcb/mjp042
Abstract | Full Text 
NANOS: a germline stem cell's guardian angel Free
Run Shen and Ting Xie
J Mol Cell Biol, Volume 2, Issue 2, April 2010, 76-77, https://doi.org/10.1093/jmcb/mjp043
Abstract | Full Text 
Molecular suicide notes: last call from apoptosing cells Free
Christoph Peter, Sebastian Wesselborg, and Kirsten Lauber
J Mol Cell Biol, Volume 2, Issue 2, April 2010, 78-80, https://doi.org/10.1093/jmcb/mjp045
Abstract | Full Text 
WD40 repeats arrange histone tails for spreading of silencing Free
Tamaki Suganuma and Jerry L. Workman
J Mol Cell Biol, Volume 2, Issue 2, April 2010, 81-83, https://doi.org/10.1093/jmcb/mjp046
Abstract | Full Text 

Reviews

Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals Free
Barbara Stecca and Ariel Ruiz i Altaba
J Mol Cell Biol, Volume 2, Issue 2, April 2010, 84-95, https://doi.org/10.1093/jmcb/mjp052
Abstract | Full Text 
ALP/Enigma PDZ-LIM domain proteins in the heart Free
Ming Zheng, Hongqiang Cheng, Indroneal Banerjee, and Ju Chen
J Mol Cell Biol, Volume 2, Issue 2, April 2010, 96-102, https://doi.org/10.1093/jmcb/mjp038
Abstract | Full Text 

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Cover: The cover illustrates Model of the regulation of GLI1, the last and critical step of the Hedgehog pathway, by oncogenes and tumor suppressors. Sequential oncogene activation and loss of tumor suppressors activates GLI1 to higher and higher levels, leading to enhanced tumor growth and stem cell self-renewal. Increasing GLI1 activity levels may drive tumor progression. The model is laid over an image of the localization of GLI1 mRNA in a human metastatic melanoma patient sample by RNA in situ hybridization. Note the presence of the cytoplasmic signal (blue) in the large melanoma cells
forming typical grape bunch-like structures. See the article by Stecca and Ruiz i Altaba in this issue and Stecca et al., 2007 PNAS for additional melanoma data.