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Volume 3, Issue 1, February 2011

Editorial

Genomic instability and cancer: an introduction Free
Zhiyuan Shen
J Mol Cell Biol, Volume 3, Issue 1, February 2011, 1-3, https://doi.org/10.1093/jmcb/mjq057
Abstract | Full Text 

Reviews

More forks on the road to replication stress recovery Free
Chris Allen, Amanda K. Ashley, Robert Hromas, and Jac A. Nickoloff
J Mol Cell Biol, Volume 3, Issue 1, February 2011, 4-12, https://doi.org/10.1093/jmcb/mjq049
Abstract | Full Text 
Prevention of DNA re-replication in eukaryotic cells Free
Lan N. Truong and Xiaohua Wu
J Mol Cell Biol, Volume 3, Issue 1, February 2011, 13-22, https://doi.org/10.1093/jmcb/mjq052
Abstract | Full Text 
Okazaki fragment maturation: nucleases take centre stage Free
Li Zheng and Binghui Shen
J Mol Cell Biol, Volume 3, Issue 1, February 2011, 23-30, https://doi.org/10.1093/jmcb/mjq048
Abstract | Full Text 
A Blm-Recql5 partnership in replication stress response Free
Xincheng Lu, Hua Lou, and Guangbin Luo
J Mol Cell Biol, Volume 3, Issue 1, February 2011, 31-38, https://doi.org/10.1093/jmcb/mjq056
Abstract | Full Text 
The role of RAD9 in tumorigenesis Free
Howard B. Lieberman, Joshua D. Bernstock, Constantinos G. Broustas, Kevin M. Hopkins, Corinne Leloup, and Aiping Zhu
J Mol Cell Biol, Volume 3, Issue 1, February 2011, 39-43, https://doi.org/10.1093/jmcb/mjq039
Abstract | Full Text 
Tumor suppressor p53 meets microRNAs Free
Zhaohui Feng, Cen Zhang, Rui Wu, and Wenwei Hu
J Mol Cell Biol, Volume 3, Issue 1, February 2011, 44-50, https://doi.org/10.1093/jmcb/mjq040
Abstract | Full Text 
Epigenetic changes of DNA repair genes in cancer Free
Christoph Lahtz and Gerd P. Pfeifer
J Mol Cell Biol, Volume 3, Issue 1, February 2011, 51-58, https://doi.org/10.1093/jmcb/mjq053
Abstract | Full Text 
"Hide-then-hit" to explain the importance of genotypic polymorphism of DNA repair genes in determining susceptibility to cancer Free
Pei-Ei Wu and Chen-Yang Shen
J Mol Cell Biol, Volume 3, Issue 1, February 2011, 59-65, https://doi.org/10.1093/jmcb/mjq054
Abstract | Full Text 
BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability Free
Amal Aly and Shridar Ganesan
J Mol Cell Biol, Volume 3, Issue 1, February 2011, 66-74, https://doi.org/10.1093/jmcb/mjq055
Abstract | Full Text 

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Cover: Regulation of DNA replication during a cell cycle. In G1, Cdt1 and Cdc6 recruit MCM2-7 to ORC-bound origins to form the pre-RC complexes. At the onset of S-phase, the activation of CDK and DDK triggers the recruitment of Cdc45 and GINS to origins to form the pre-IC complexes. In S and G2, pre-RC reassembly is prevented by Cdt1 degradation or Geminin binding and by nuclear export of Cdc6. See pages 13-22 by Truong and Wu for details.