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Volume 4, Issue 3, June 2012

Editorial

Systems biology for complex diseases Free
Luonan Chen and Jiarui Wu
J Mol Cell Biol, Volume 4, Issue 3, June 2012, 125-126, https://doi.org/10.1093/jmcb/mjs022
Abstract | Full Text 

Reviews

Quantitative mathematical modeling of PSA dynamics of prostate cancer patients treated with intermittent androgen suppression Free
Yoshito Hirata, Koichiro Akakura, Celestia S. Higano, Nicholas Bruchovsky, and Kazuyuki Aihara
J Mol Cell Biol, Volume 4, Issue 3, June 2012, 127-132, https://doi.org/10.1093/jmcb/mjs020
Abstract | Full Text 
Regenerative medicine using adult neural stem cells: the potential for diabetes therapy and other pharmaceutical applications Free
Tomoko Kuwabara and Makoto Asashima
J Mol Cell Biol, Volume 4, Issue 3, June 2012, 133-139, https://doi.org/10.1093/jmcb/mjs016
Abstract | Full Text 

Articles

Coexpression network analysis in chronic hepatitis B and C hepatic lesions reveals distinct patterns of disease progression to hepatocellular carcinoma Free
Danning He, Zhi-Ping Liu, Masao Honda, Shuichi Kaneko, and Luonan Chen
J Mol Cell Biol, Volume 4, Issue 3, June 2012, 140-152, https://doi.org/10.1093/jmcb/mjs011
Abstract | Full Text 
The crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor Free
Jae-Kyung Won, Hee Won Yang, Sung-Young Shin, Jong Hoon Lee, Won Do Heo, and Kwang-Hyun Cho
J Mol Cell Biol, Volume 4, Issue 3, June 2012, 153-163, https://doi.org/10.1093/jmcb/mjs021
Abstract | Full Text 
Splicing variant of AIMP2 as an effective target against chemoresistant ovarian cancer Free
Jin Woo Choi, Jeong-Won Lee, Jun Ki Kim, Hye-Kyung Jeon, Jung-Joo Choi, Dae Gyu Kim, Byoung-Gie Kim, Do-Hyun Nam, Hong Joong Kim, Seok Hyun Yun, and Sunghoon Kim
J Mol Cell Biol, Volume 4, Issue 3, June 2012, 164-173, https://doi.org/10.1093/jmcb/mjs018
Abstract | Full Text 

Letters to the Editor

Hypoxia and miscoupling between reduced energy efficiency and signaling to cell proliferation drive cancer to grow increasingly faster Free
Juan Cui, Xizeng Mao, Victor Olman, P. J. Hastings, and Ying Xu
J Mol Cell Biol, Volume 4, Issue 3, June 2012, 174-176, https://doi.org/10.1093/jmcb/mjs017
Abstract | Full Text 
A novel strategy for deciphering dynamic conservation of gene expression relationship Free
Liyun Yuan, Guohui Ding, Y. Eugene Chen, Zhe Chen, and Yixue Li
J Mol Cell Biol, Volume 4, Issue 3, June 2012, 177-179, https://doi.org/10.1093/jmcb/mjs014
Abstract | Full Text 
Molecular analysis of FMR1 reactivation in fragile-X induced pluripotent stem cells and their neuronal derivatives Free
Ori Bar-Nur, Inbal Caspi, and Nissim Benvenisty
J Mol Cell Biol, Volume 4, Issue 3, June 2012, 180-183, https://doi.org/10.1093/jmcb/mjs007
Abstract | Full Text 
HIF-1α binding to the Epac1 promoter recruits hematopoietic stem cells to the ischemic brain following stroke Free
Ted Weita Lai, Shinn-Zong Lin, Hsu-Tung Lee, Jia-Rong Fan, Yung-Hsiang Hsu, Hsiao-Jung Wang, Yung-Luen Yu, and Woei-Cherng Shyu
J Mol Cell Biol, Volume 4, Issue 3, June 2012, 184-187, https://doi.org/10.1093/jmcb/mjs009
Abstract | Full Text 

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Cover: A systems biological approach based on mathematical modeling and biochemical experimentation revealed that MEK inhibitor disrupts the negative feedback loops from ERK to SOS and GAB1 while activates the positive feedback loop composed of GAB1, Ras, and PI3K, which induces the bypass of ERK signal to PI3K signal and ultimately leads to the emergence of resistance to MEK inhibitor. See pages 153-163 by Won et al. for details.