Volume 4, Issue 5, October 2012

Editorial

Genotoxic stresses and protein modifications Free
Jiarui Wu
J Mol Cell Biol, Volume 4, Issue 5, October 2012, 269-269, https://doi.org/10.1093/jmcb/mjs051
Abstract | Full Text 

Review

Enlightening molecular mechanisms through study of protein interactions Free
Josep Rizo, Michael K. Rosen, and Kevin H. Gardner
J Mol Cell Biol, Volume 4, Issue 5, October 2012, 270-283, https://doi.org/10.1093/jmcb/mjs036
Abstract | Full Text 

Articles

Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress Free
André Brandl, Tobias Wagner, Katharina M. Uhlig, Shirley K. Knauer, Roland H. Stauber, Frauke Melchior, Günter Schneider, Thorsten Heinzel, and Oliver H. Krämer
J Mol Cell Biol, Volume 4, Issue 5, October 2012, 284-293, https://doi.org/10.1093/jmcb/mjs013
Abstract | Full Text 
DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage Free
Laura Zannini, Giacomo Buscemi, Ja-Eun Kim, Enrico Fontanella, and Domenico Delia
J Mol Cell Biol, Volume 4, Issue 5, October 2012, 294-303, https://doi.org/10.1093/jmcb/mjs035
Abstract | Full Text 
Activation of the ATM-Snail pathway promotes breast cancer metastasis Free
Mianen Sun, Xiaojing Guo, Xiaolong Qian, Haibo Wang, Chunying Yang, Kathryn L. Brinkman, Monica Serrano-Gonzalez, Richard S. Jope, Binhua Zhou, David A. Engler, Ming Zhan, Stephen T.C. Wong, Li Fu, and Bo Xu
J Mol Cell Biol, Volume 4, Issue 5, October 2012, 304-315, https://doi.org/10.1093/jmcb/mjs048
Abstract | Full Text 
Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways Free
Moisés Pérez, Carmen García-Limones, Inés Zapico, Anabel Marina, M. Lienhard Schmitz, Eduardo Muñoz, and Marco A. Calzado
J Mol Cell Biol, Volume 4, Issue 5, October 2012, 316-330, https://doi.org/10.1093/jmcb/mjs047
Abstract | Full Text 
SUV39H1 orchestrates temporal dynamics of centromeric methylation essential for faithful chromosome segregation in mitosis Free
Lingluo Chu, Tongge Zhu, Xing Liu, Ruoying Yu, Methode Bacanamwo, Zhen Dou, Youjun Chu, Hanfa Zou, Gary H. Gibbons, Dongmei Wang, Xia Ding, and Xuebiao Yao
J Mol Cell Biol, Volume 4, Issue 5, October 2012, 331-340, https://doi.org/10.1093/jmcb/mjs023
Abstract | Full Text 

Letters to the Editor

Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155 Free
Xing Cai, Yuan Yin, Ningzhu Li, Dihan Zhu, Junfeng Zhang, Chen-Yu Zhang, and Ke Zen
J Mol Cell Biol, Volume 4, Issue 5, October 2012, 341-343, https://doi.org/10.1093/jmcb/mjs044
Abstract | Full Text 
Shotgun and targeted proteomics reveal that pre-surgery serum levels of LRG1, SAA, and C4BP may refine prognosis of resected squamous cell lung cancer Free
Yan-Sheng Liu, Xiao-Yang Luo, Qing-Run Li, Hong Li, Chen Li, Hong Ni, Rong-Xia Li, Rui Wang, Hai-chuan Hu, Yun-jian Pan, Hai-Quan Chen, and Rong Zeng
J Mol Cell Biol, Volume 4, Issue 5, October 2012, 344-347, https://doi.org/10.1093/jmcb/mjs050
Abstract | Full Text 

Perspective

MAP kinases and histone modification Free
Tamaki Suganuma and Jerry L. Workman
J Mol Cell Biol, Volume 4, Issue 5, October 2012, 348-350, https://doi.org/10.1093/jmcb/mjs043
Abstract | Full Text 
Cover: HDAC2 sumoylation regulates p53 activities. Catalytically active sumoylatable HDAC2 locks the tumor suppressor p53 in an inactive state. The mechanism by which HDAC2 negatively controls p53-dependent transcription relies on the ability of HDAC2 to become sumoylated at K462. Consequently, HDAC2 binds to and deacetylates p53 at K320 which strongly attenuates its DNA binding. This process suppresses the expression of the pro-apoptotic factors BAX and PIG3, of the cell cycle regulator p21 and of the E3 ubiquitin-ligase HDM2. It also blocks the p53-mediated transcriptional repression of the anti-apoptotic protein Survivin (Surv). This ultimately modulates the apoptotic response to genotoxic stress. See pages 284-293 by Brandl et al. for details.