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Volume 5, Issue 1, February 2013

Editorial

New way to tumor therapeutics Free
Jiarui Wu
J Mol Cell Biol, Volume 5, Issue 1, February 2013, 1-2, https://doi.org/10.1093/jmcb/mjt001
Abstract | Full Text 

Articles

A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1 Free
Qing Xu, Yue Jiang, Yu Yin, Qi Li, Jun He, Yi Jing, Yan-Ting Qi, Qian Xu, Wei Li, Bo Lu, Stephen S. Peiper, Bing-Hua Jiang, and Ling-Zhi Liu
J Mol Cell Biol, Volume 5, Issue 1, February 2013, 3-13, https://doi.org/10.1093/jmcb/mjs049
Abstract | Full Text 
New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells Free
Soo Ok Lee, Zhifang Ma, Chiuan-Ren Yeh, Jie Luo, Tzu-Hua Lin, Kuo-Pao Lai, Shinichi Yamashita, Liang Liang, Jing Tian, Lei Li, Qi Jiang, Chiung-Kuei Huang, Yuanjie Niu, Shuyuan Yeh, and Chawnshang Chang
J Mol Cell Biol, Volume 5, Issue 1, February 2013, 14-26, https://doi.org/10.1093/jmcb/mjs042
Abstract | Full Text 
HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop Free
Vera V. Saul, Laureano de la Vega, Maja Milanovic, Marcus Krüger, Thomas Braun, Karin Fritz-Wolf, Katja Becker, and M. Lienhard Schmitz
J Mol Cell Biol, Volume 5, Issue 1, February 2013, 27-38, https://doi.org/10.1093/jmcb/mjs053
Abstract | Full Text 
USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6 Free
Xiao He, Yi Li, Chao Li, Li-Juan Liu, Xiao-Dong Zhang, Yu Liu, and Hong-Bing Shu
J Mol Cell Biol, Volume 5, Issue 1, February 2013, 39-47, https://doi.org/10.1093/jmcb/mjs024
Abstract | Full Text 
Open–closed motion of Mint2 regulates APP metabolism Free
Xingqiao Xie, Xiaojie Yan, Zheng Wang, Hao Zhou, Wentao Diao, Weihong Zhou, Jiafu Long, and Yuequan Shen
J Mol Cell Biol, Volume 5, Issue 1, February 2013, 48-56, https://doi.org/10.1093/jmcb/mjs033
Abstract | Full Text 

Letters to the Editor

Mediator MED15 modulates transforming growth factor beta (TGFβ)/Smad signaling and breast cancer cell metastasis Free
Meng Zhao, Xu Yang, Yu Fu, Haifang Wang, Yuanheng Ning, Jun Yan, Ye-Guang Chen, and Gang Wang
J Mol Cell Biol, Volume 5, Issue 1, February 2013, 57-60, https://doi.org/10.1093/jmcb/mjs054
Abstract | Full Text 
Akt2 knockout preserves cardiac function in high-fat diet-induced obesity by rescuing cardiac autophagosome maturation Free
Xihui Xu, Yinan Hua, Nair Sreejayan, Yingmei Zhang, and Jun Ren
J Mol Cell Biol, Volume 5, Issue 1, February 2013, 61-63, https://doi.org/10.1093/jmcb/mjs055
Abstract | Full Text 
Functional and structural characterization of DNMT2 from Spodoptera frugiperda Free
Sisi Li, Jiamu Du, Hui Yang, Juan Yin, Jianping Ding, and Jiang Zhong
J Mol Cell Biol, Volume 5, Issue 1, February 2013, 64-66, https://doi.org/10.1093/jmcb/mjs057
Abstract | Full Text 
Induction of microRNA resistance and secretion in differentiating human endometrial stromal cells
Kunal M. Shah, Jason Webber, Raffaella Carzaniga, Deborah M. Taylor, Luca Fusi, Aled Clayton, Jan J. Brosens, Geraldine Hartshorne, and Mark Christian
J Mol Cell Biol, Volume 5, Issue 1, February 2013, 67-70, https://doi.org/10.1093/jmcb/mjs058
Abstract | Full Text 

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Cover: Downregulation of miR-148a and miR-152 in breast cancer cells is due to the DNA methylation of their promoters induced by DNMT1 overexpression. miR-148a and miR-152 suppression increases expression of their direct targets IGF-IR and IRS1 as well as DNMT1, which activates AKT and ERK signaling pathways to increase HIF-1a and VEGF expression for regulating tumor growth and angiogenesis. See pages 3-13 by Xu et al. for details.