Volume 7, Issue 2, April 2015

Editorial

New insights into the regulation of tumorigenesis Free
Jiarui Wu
J Mol Cell Biol, Volume 7, Issue 2, April 2015, Pages 91-91, https://doi.org/10.1093/jmcb/mjv024
Abstract | Full Text 

Review

Ribosomal proteins: functions beyond the ribosome Free
Xiang Zhou, Wen-Juan Liao, Jun-Ming Liao, Peng Liao, and Hua Lu
J Mol Cell Biol, Volume 7, Issue 2, April 2015, Pages 92-104, https://doi.org/10.1093/jmcb/mjv014
Abstract | Full Text 

Articles

p53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers Free
Xinsen Ruan, Qiao Zuo, Hao Jia, Jenny Chau, Jinlin Lin, Junping Ao, Xuechun Xia, Huijuan Liu, Samy L. Habib, Chuangang Fu, and Baojie Li
J Mol Cell Biol, Volume 7, Issue 2, April 2015, Pages 105-118, https://doi.org/10.1093/jmcb/mjv015
Abstract | Full Text 
Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity Free
Jason Howitt, Ley-Hian Low, Ulrich Putz, Anh Doan, Jenny Lackovic, Choo-Peng Goh, Jenny Gunnersen, John Silke, and Seong-Seng Tan
J Mol Cell Biol, Volume 7, Issue 2, April 2015, Pages 119-131, https://doi.org/10.1093/jmcb/mjv020
Abstract | Full Text 
PI3K/mTOR mediate mitogen-dependent HDAC1 phosphorylation in breast cancer: a novel regulation of estrogen receptor expression Free
Simona Citro, Claudia Miccolo, Laura Meloni, and Susanna Chiocca
J Mol Cell Biol, Volume 7, Issue 2, April 2015, Pages 132-142, https://doi.org/10.1093/jmcb/mjv021
Abstract | Full Text 
Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN 
Kerstin Menck, Christian Scharf, Annalen Bleckmann, Lydia Dyck, Ulrike Rost, Dirk Wenzel, Vishnu M. Dhople, Laila Siam, Tobias Pukrop, Claudia Binder, and Florian Klemm
J Mol Cell Biol, Volume 7, Issue 2, April 2015, Pages 143-153, https://doi.org/10.1093/jmcb/mju047
Abstract | Full Text 
ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis Free
Shan Wang, Siying Wang, Lihua Yang, Hua Guo, Xue Kong, Lin Yuan, Guichun Xing, Fuchu He, and Lingqiang Zhang
J Mol Cell Biol, Volume 7, Issue 2, April 2015, Pages 154-167, https://doi.org/10.1093/jmcb/mjv010
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Function coupling of otoferlin with GAD65 acts to modulate GABAergic activity Free
Wu Wu, Mona N. Rahman, Jun Guo, Natalie Roy, Lihua Xue, Catherine M. Cahill, Shetuan Zhang, and Zongchao Jia
J Mol Cell Biol, Volume 7, Issue 2, April 2015, Pages 168-179, https://doi.org/10.1093/jmcb/mjv011
Abstract | Full Text 

Letter to the Editor

O-GlcNAcylation of MLL5β is essential for MLL5β–AP-1 transcription complex assembly at the HPV16/18-long control region Free
Dawn Sijin Nin, Weitai Huang, Muzaffar Ali, Chow Wenn Yew, Tatiana G. Kutateladze, and Lih-Wen Deng
J Mol Cell Biol, Volume 7, Issue 2, April 2015, Pages 180-183, https://doi.org/10.1093/jmcb/mjv009
Abstract | Full Text 

Corrigendum

COL4A3 mutations cause focal segmental glomerulosclerosis Free
Jingyuan Xie, Xiaoxi Wu, Hong Ren, Weiming Wang, Zhaohui Wang, Xiaoxia Pan, Xu Hao, Jun Tong, Jun Ma, Zhibin Ye, Guoyu Meng, Yufei Zhu, Krzysztof Kiryluk, Xiangyin Kong, Landian Hu, and Nan Chen
J Mol Cell Biol, Volume 7, Issue 2, April 2015, Pages 184-184, https://doi.org/10.1093/jmcb/mjv023
Abstract | Full Text 
Cover: Schematic representation of mitogen-mediated HDAC1 phosphorylation and ERα transcriptional regulation. Upper left: during starvation, receptor tyrosine kinases (RTKs) are not stimulated and not able to activate the PI3K/mTOR pathway. Under these conditions, HDAC1 is not phosphorylated, ERα promoter is more acetylated, and ERα is more expressed. Upper right: upon RTKs activation by hormones and growth factors, PI3K/mTOR are activated. The subsequent activation of S6K1 controls HDAC1 phosphorylation, affecting its positive role in ERα regulation, reducing ERα promoter acetylation and gene expression. Bottom: in the presence of rapamycin, S6K1 is not active and not able to phosphorylate HDAC1, thus promoting ERα promoter acetylation and gene expression.