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Volume 7, Issue 4, August 2015

Editorial

Innovative methods and techniques for frontiers of life science Free
Jiarui Wu, Editor-in-Chief
J Mol Cell Biol, Volume 7, Issue 4, August 2015, 283-283, https://doi.org/10.1093/jmcb/mjv051
Abstract | Full Text 

Articles

Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9 
Jinhuan Li, Jia Shou, Ya Guo, Yuanxiao Tang, Yonghu Wu, Zhilian Jia, Yanan Zhai, Zhifeng Chen, Quan Xu, and Qiang Wu
J Mol Cell Biol, Volume 7, Issue 4, August 2015, 284-298, https://doi.org/10.1093/jmcb/mjv016
Abstract | Full Text 
MBRidge: an accurate and cost-effective method for profiling DNA methylome at single-base resolution Free
Wanshi Cai, Fengbiao Mao, Huajing Teng, Tao Cai, Fangqing Zhao, Jinyu Wu, and Zhong Sheng Sun
J Mol Cell Biol, Volume 7, Issue 4, August 2015, 299-313, https://doi.org/10.1093/jmcb/mjv037
Abstract | Full Text 
Integrative analyses of RNA editing, alternative splicing, and expression of young genes in human brain transcriptome by deep RNA sequencing Free
Dong-Dong Wu, Ling-Qun Ye, Yan Li, Yan-Bo Sun, Yi Shao, Chunyan Chen, Zhu Zhu, Li Zhong, Lu Wang, David M. Irwin, Yong E. Zhang, and Ya-Ping Zhang
J Mol Cell Biol, Volume 7, Issue 4, August 2015, 314-325, https://doi.org/10.1093/jmcb/mjv043
Abstract | Full Text 
Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro Free
Ling Shuai, Yukai Wang, Mingzhu Dong, Xuepeng Wang, Lisi Sang, Mei Wang, Haifeng Wan, Guanzheng Luo, Tiantian Gu, Yan Yuan, Chunjing Feng, Fei Teng, Wei Li, Xiuying Liu, Tianda Li, Liu Wang, Xiu-Jie Wang, Xiao-Yang Zhao, and Qi Zhou
J Mol Cell Biol, Volume 7, Issue 4, August 2015, 326-337, https://doi.org/10.1093/jmcb/mjv044
Abstract | Full Text 
PTPROt maintains T cell immunity in the microenvironment of hepatocellular carcinoma Free
Jiajie Hou, Lei Deng, Han Zhuo, Zhe Lin, Yun Chen, Runqiu Jiang, Dianyu Chen, Xudong Zhang, Xingxu Huang, and Beicheng Sun
J Mol Cell Biol, Volume 7, Issue 4, August 2015, 338-350, https://doi.org/10.1093/jmcb/mjv047
Abstract | Full Text 
Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation Free
Fahima Madouri, Noëlline Guillou, Louis Fauconnier, Tiffany Marchiol, Nathalie Rouxel, Pauline Chenuet, Aurélie Ledru, Lionel Apetoh, François Ghiringhelli, Mathias Chamaillard, Song Guo Zheng, Fabrice Trovero, Valérie F.J. Quesniaux, Bernhard Ryffel, and Dieudonnée Togbe
J Mol Cell Biol, Volume 7, Issue 4, August 2015, 351-365, https://doi.org/10.1093/jmcb/mjv012
Abstract | Full Text 
Hot spots of DNA double-strand breaks and genomic contacts of human rDNA units are involved in epigenetic regulation
Nickolai A. Tchurikov, Daria M. Fedoseeva, Dmitri V. Sosin, Anastasia V. Snezhkina, Nataliya V. Melnikova, Anna V. Kudryavtseva, Yuri V. Kravatsky, and Olga V. Kretova
J Mol Cell Biol, Volume 7, Issue 4, August 2015, 366-382, https://doi.org/10.1093/jmcb/mju038
Abstract | Full Text 

Letter to the Editor

Quantitative detection of in vivo physical protein–protein interactions based on DNA sequence recognition Free
Siwei Luo, Yihua Jiang, Zhi Liang, and Jiarui Wu
J Mol Cell Biol, Volume 7, Issue 4, August 2015, 383-386, https://doi.org/10.1093/jmcb/mjv036
Abstract | Full Text 

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Cover: Targeted genome editing by CRISPR has revolutionized life science and medical research as well as biotechnology industry and agriculture. The cover shows that efficient DNA fragment editing can be easily achieved by using CRISPR/Cas9 system. Cas9 nuclease guided by a pair of sgRNAs generates double-strand breaks (DSBs) at 3-bp upstream of protospacer adjacent motif (PAM) sites. Inversion, duplication, and deletion of DNA fragments can then be generated through DNA repair pathways. This CRISPR method is useful in genome engineering for studying millions of DNA regulatory elements in 3D genome topology and gene regulation, as well as mechanisms of development and disease progression. See pages 284–298 by Li et al. in this issue and Guo et al. in Cell (doi:10.1016/j.cell.2015.07.038) for details.