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Volume 9, Issue 1, February 2017

Editorial

p53 and MDM2: their Yin-Yang intimacy Free
Hua Lu
J Mol Cell Biol, Volume 9, Issue 1, February 2017, 1-2, https://doi.org/10.1093/jmcb/mjx003
Abstract | Full Text 

Reviews

Mdm2 as a chromatin modifier
Magdalena Wienken, Ute M. Moll, and Matthias Dobbelstein
J Mol Cell Biol, Volume 9, Issue 1, February 2017, 74-80, https://doi.org/10.1093/jmcb/mjw046
Abstract | Full Text 
Modulation of the p53/MDM2 interplay by HAUSP inhibitors Free
Omid Tavana, and Wei Gu
J Mol Cell Biol, Volume 9, Issue 1, February 2017, 45-52, https://doi.org/10.1093/jmcb/mjw049
Abstract | Full Text 
Role of Mdm2 and Mdmx in DNA repair
Christine M. Eischen
J Mol Cell Biol, Volume 9, Issue 1, February 2017, 69-73, https://doi.org/10.1093/jmcb/mjw052
Abstract | Full Text 
Negative auto-regulators trap p53 in their web Free
Xiang Zhou, Bo Cao, and Hua Lu
J Mol Cell Biol, Volume 9, Issue 1, February 2017, 62-68, https://doi.org/10.1093/jmcb/mjx001
Abstract | Full Text 
Anatomy of Mdm2 and Mdm4 in evolution
Ban Xiong Tan, Hoe Peng Liew, Joy S. Chua, Farid J. Ghadessy, Yaw Sing Tan, David P. Lane, and Cynthia R. Coffill
J Mol Cell Biol, Volume 9, Issue 1, February 2017, 3-15, https://doi.org/:10.1093/jmcb/mjx002
Abstract | Full Text 
Mdm proteins: critical regulators of embryogenesis and homoeostasis
Sydney M. Moyer, Connie A. Larsson, and Guillermina Lozano
J Mol Cell Biol, Volume 9, Issue 1, February 2017, 16-25, https://doi.org/10.1093/jmcb/mjx004
Abstract | Full Text 
Regulation of kidney development by the Mdm2/Mdm4–p53 axis
Samir El-Dahr, Sylvia Hilliard, and Zubaida Saifudeen
J Mol Cell Biol, Volume 9, Issue 1, February 2017, 26-33, https://doi.org/10.1093/jmcb/mjx005
Abstract | Full Text 
Mouse modelling of the MDM2/MDMX−p53 signalling axis 
Nicole R. Tackmann, and Yanping Zhang
J Mol Cell Biol, Volume 9, Issue 1, February 2017, 34-44, https://doi.org/10.1093/jmcb/mjx006
Abstract | Full Text 
The role of MDM2 and MDM4 in breast cancer development and prevention
Sue Haupt, Reshma Vijayakumaran, Panimaya Jeffreena Miranda, Andrew Burgess,Elgene Lim, and Ygal Haupt
J Mol Cell Biol, Volume 9, Issue 1, February 2017, 53-61, https://doi.org/10.1093/jmcb/mjx007
Abstract | Full Text 

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Cover: The tangled and intimate relationship between evolutionarily conserved MDM2 and p53, analogized by the fine balance of Yin (p53) and Yang (MDM2) in a negative feedback regulatory axis, is essentially important for embryogenesis, stem cell renewal, organogenesis, adult homeostasis, genomic stability, and cancer development in the animal kingdom including humans. If off balance, on one hand, cancer develops due to the inactivation of p53 by MDM2 or other oncogenes, such as MDMX, and on the other hand, aberrant development occurs as a result of abnormally activated p53 caused by loss or inactivation of MDM2 or MDMX. Hence, a fine balance is required for normal life, i.e. higher eukaryotic cells to proliferate and grow happily, embryos to develop normally, specific organs to form correctly, and animals to live healthily. See pages 1–2 by Lu for details.