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Organoid technology for tissue engineering
Juan He1 , Xiaoyu Zhang1 , Xinyi Xia1 , Ming Han1 , Fei Li1 , Chunfeng Li1 , Yunguang Li1 , Dong Gao1,2,*
1State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China
2Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
*Correspondence to:Dong Gao , Email:dong.gao@sibcb.ac.cn
J Mol Cell Biol, Volume 12, Issue 8, August 2020, Pages 569-579  https://doi.org/10.1093/jmcb/mjaa012
Keyword: organoid, tissue engineering, 3D culture

For centuries, attempts have been continuously made to artificially reconstitute counterparts of in vivo organs from their tissues or cells. Only in the recent decade has organoid technology as a whole technological field systematically emerged and been shown to play important roles in tissue engineering. Based on their self-organizing capacities, stem cells of versatile organs, both harvested and induced, can form 3D structures that are structurally and functionally similar to their in vivo counterparts. These organoid models provide a powerful platform for elucidating the development mechanisms, modeling diseases, and screening drug candidates. In this review, we will summarize the advances of this technology for generating various organoids of tissues from the three germ layers and discuss their drawbacks and prospects for tissue engineering.