Letter to the Editor

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Senescent bone marrow microenvironment promotes Nras-mutant leukemia
Peiqing Zhou1,2,3,4,† , Chengxiang Xia1,3,4,† , Tongjie Wang5 , Yong Dong1 , Qitong Weng1,2 , Xiaofei Liu1 , Yang Geng1 , Jinyong Wang1,2,3,4,5,* , Juan Du1,2,3,4,*
1CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
2University of Chinese Academy of Sciences, Beijing 100049, China
3Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
4Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
5Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou 510005, China
These authors contributed equally to this work.
*Correspondence to:Jinyong Wang , Email:wang_jinyong@gibh.ac.cn Juan Du , Email:du_juan@gibh.ac.cn
J Mol Cell Biol, Volume 13, Issue 1, January 2021, Pages 72-74  https://doi.org/10.1093/jmcb/mjaa062

Dear Editor,

In recent years, there is growing interest regarding the roles of senescent bone marrow (BM) microenvironment in the initiation of leukemia. Aged mice transplanted with AML1-ETO (AML1-ETO fusion protein)-positive hematopoietic stem cells (HSCs) present with a significant increase in the frequency of AML-ETO-positive early progenitor cells in BM as well as an increase of immature myeloid cells compared to young recipients (Vas et al., 2012). BM mesenchymal stem cells (MSCs) from myelodysplastic syndromes (MDS) animal models and MDS patients exhibit impaired proliferation and differentiation potentials, abnormal cytokine secretion, and dysregulated gene expression profile (Lopez-Villar et al., 2009; Geyh et al., 2013; Mattiucci et al., 2018). However, the causal relationship between senescent BM microenvironment and leukemia development is unclear. Whether senescent BM microenvironment initiates or accelerates leukemia development remains unknown.