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Current knowledge of Krüppel-like factor 5 and vascular remodeling: providing insights for therapeutic strategies
Ziyan Xie1 , Junye Chen2 , Chenyu Wang1 , Jiahao Zhang1 , Yanxiang Wu1 , Xiaowei Yan1,*
1Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China
2Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China
*Correspondence to:Xiaowei Yan , Email:yanxw@pumch.cn
J Mol Cell Biol, Volume 13, Issue 2, February 2021, Pages 79-90  https://doi.org/10.1093/jmcb/mjaa080
Keyword: Krüppel-like factor 5 (KLF5), vascular remodeling, inflammation, angiogenesis, drug development, microRNA

Vascular remodeling is a pathological basis of various disorders. Therefore, it is necessary to understand the occurrence, prevention, and treatment of vascular remodeling. Krüppel-like factor 5 (KLF5) has been identified as a significant factor in cardiovascular diseases during the last two decades. This review provides a mechanism network of function and regulation of KLF5 in vascular remodeling based on newly published data and gives a summary of its potential therapeutic applications. KLF5 modulates numerous biological processes, which play essential parts in the development of vascular remodeling, such as cell proliferation, phenotype switch, extracellular matrix deposition, inflammation, and angiogenesis by altering downstream genes and signaling pathways. Considering its essential functions, KLF5 could be developed as a potent therapeutic target in vascular disorders.