Research Advance

< Previous         Next >  
T cell metabolism in obesity and beyond: comments on ‘DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-γ production’
Haiyan Zhou1 , Feng Liu1,2,*
1National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, China
2Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
*Correspondence to:Feng Liu ,
J Mol Cell Biol, Volume 13, Issue 5, May 2021, 389-391,

T cells have long been known as the core of adaptive immunity and play pivotal roles in host defense (Zhu et al., 2010). There are two main types of T cells in our body, cytotoxic T cells (CD8+) and helper T (Th) cells (CD4+), the latter comprised of Th1, Th2, Th17, and Treg subsets. Increasing evidence supports that metabolic reprogramming of T cells leads to dramatic changes in tissue microenvironments, which may alter whole-body energy homeostasis and metabolism, beyond their roles in adaptive immunity (Varanasi et al., 2020).