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Obesity: causes, consequences, treatments, and challenges 
Weiping Jia1,* , Feng Liu2,*
1Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
2Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
*Correspondence to:Weiping Jia , Email:wpjia@sjtu.edu.cn Feng Liu , Email:liuf@uthscsa.edu
J Mol Cell Biol, Volume 13, Issue 7, July 2021, Pages 463-465  https://doi.org/10.1093/jmcb/mjab056

Obesity has become a global epidemic and is one of today’s most public health problems worldwide. Obesity poses a major risk for a variety of serious diseases including diabetes mellitus, non-alcoholic liver disease (NAFLD), cardiovascular disease, hypertension and stroke, and certain forms of cancer (Bluher, 2019).