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Knockdown of insulin-like growth factor 2 gene disrupts mitochondrial functions in the liv
Weiwei Gui1 , Yiyi Zhu , Shuiya Sun1 , Weifen Zhu1 , Bowen Tan3 , Hanxin Zhao1 , Chengxin Shang1 , Fenping Zheng1 , Xihua Lin1,4,* , Hong Li1,*
1Department of Endocrinology, The Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
3College of Medicine, Zhejiang University, Hangzhou, China
4Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, The Affiliated Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
*Correspondence to:Xihua Lin , Email:linxihua@zju.edu.cn Hong Li , Email:srrshnfm@zju.edu.cn
J Mol Cell Biol, Volume 13, Issue 8, August 2021, Pages 543-555  https://doi.org/10.1093/jmcb/mjab030
Keyword: insulin-like growth factor 2, mitochondrial function, nonalcoholic fatty liver
Even though insulin-like growth factor 2 (IGF2) has been reported to be overexpressed in nonalcoholic fatty liver disease (NAFLD), its role in the progression of NAFLD and the potential mechanism remain largely unclear....