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Effects of SARS-CoV-2 infection on human reproduction
Ming Yang1,3,5,7,† , Jing Wang1,2,† , Yidong Chen1,3,5,7 , Siming Kong1,3,5,7 , Jie Qiao1,2,3,4,5,6,7,*
1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China
2National Clinical Research Center for Obstetrics and Gynecology, Beijing 100191, China
3Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China
4Beijing Advanced Innovation Center for Genomics, Beijing 100871, China
5Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
6Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Peking University, Beijing 100871, China
7Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
These authors contributed equally to this work.
*Correspondence to:Jie Qiao ,
J Mol Cell Biol, Volume 13, Issue 10, October 2021, 695-704,
Keyword: COVID-19, SARS-CoV-2, reproduction, vertical transmission

The worldwide infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impacts human health and life on multiple levels. People infected with SARS-CoV-2 suffer from physical disorders and psychological distress. At present, no direct evidence indicates that SARS-CoV-2 negatively influences human reproduction, and the possibility that gametes and embryos are affected requires further investigation. To evaluate the potential effects of SARS-CoV-2 infection on human reproduction and fetal health, this review summarizes the basic and clinical research of SARS-CoV-2 on reproduction up to date, hoping to offer guidance and advice to people at reproductive age and provide clues for the prevention and treatment of associated diseases.