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Mitotic inactivation of the cGAS‒MITA/STING pathways
Li Zhong , Hong-Bing Shu*
Department of Infectious Diseases, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Research Unit of Innate Immune and Inflammatory Diseases of the Chinese Academy of Medical Sciences, Wuhan 430071, China
*Correspondence to:Hong-Bing Shu , Email:shuh@whu.edu.cn
J Mol Cell Biol, Volume 13, Issue 10, October 2021, Pages 721-727  https://doi.org/10.1093/jmcb/mjab061
Keyword: cGAS, MITA, STING, mitosis, innate immune response, DNA

The cyclic guanosine monophosphate‒adenosine monophosphate synthase (cGAS)‒mediator of interferon response factor 3 activation/stimulator of interferon genes (MITA/STING) axis has emerged as a major pathway, which senses microbial or mislocated cellular DNA in the cytosol to trigger innate immune responses. cGAS senses cytosolic DNA without a preference of self- or nonself-DNA. How the cGAS‒MITA/STING axis is inactivated upon nuclear envelope breakdown (NEBD) at mitotic entry in vertebrate cells to avoid self-DNA sensing remains unclear until very recently. In this review, we summarize the recent advances on how cGAS responds to chromosomes upon NEBD and the mechanisms involved in the inactivation of the cGAS‒MITA/STING pathways in mitosis.