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The molecular regulation of autophagy in antimicrobial immunity
Chuan Qin , Yalan Lu , Lin Bai , Kewei Wang*
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Comparative Medical Center,Beijing 100021, China
*Correspondence to:Kewei Wang ,
J Mol Cell Biol, Volume 14, Issue 4, April 2022, mjac015,
Keyword: autophagy, microbe, antimicrobial immunity, endoplasmic reticulum stress, unfolded protein response, apoptosis, infectious disease

Autophagy is a catabolic process that can degrade worn-out organelles and invading pathogens. The activation of autophagy regulates innate and adaptive immunity, playing a key role in the response to microbial invasion. Microbial infection may cause different consequences such as the elimination of invaders through autophagy or xenophagy, host cell death, and symbiotic relationships. Pathogens adapt to the autophagy mechanism and further relieve intracellular stress, which is conducive to host cell survival and microbial growth. The regulation of autophagy forms a complex network through which host immunity is modulated, resulting in a variety of pathophysiological manifestations. Modification of the autophagic pathway is an essential target for the development of antimicrobial drugs.