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Supplementation of nicotinamide mononucleotide improves the quality of postovulatory aged porcine oocytes
Yilong Miao1,† , Zhaokang Cui1,† , Xiaotong Zhu1 , Qian Gao2 , Bo Xiong1,*
1College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
2College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
These authors contributed equally to this work.
*Correspondence to:Bo Xiong , Email:xiongbo@njau.edu.cn
J Mol Cell Biol, Volume 14, Issue 4, April 2022, mjac025,  https://doi.org/10.1093/jmcb/mjac025

Dear Editor,

Postovulatory aging would occur to impair the oocyte quality in a time-dependent manner if ovulated oocytes are not fertilized within the optimal timing in the oviduct or in the dishes (Trapphoff et al., 2016), which might result in the early pregnancy failure in vivo and adverse outcome of assisted reproductive technology (ART) in vitro (Nagy et al., 1993Wilcox et al., 1998). However, the effective approaches to preventing the postovulatory aging-induced oocyte deterioration are still underexplored. We recently reported that supplementation of nicotinamide mononucleotide (NMN), a synthetic precursor of NAD+, which is an essential cofactor for enzymes’ functioning in almost all critical cellular metabolic reactions (Imai and Guarente, 2014Canto et al., 2015), reverses the declining quality of maternally aged mouse oocytes (Miao et al., 2020).