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Autocrine motility factor receptor as a therapeutic target for asthma: comments on ‘AMFR drives allergic asthma development by promoting alveolar macrophage-derived GM-CSF production’
Huihui Zhang , Feng Qian* , Lei Sun*
Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
*Correspondence to:Feng Qian , Lei Sun ,
J Mol Cell Biol, Volume 14, Issue 5, May 2022, mjac032,

Asthma is a chronic inflammatory disease characterized by airway hyper-responsiveness and tissue remodeling (Nobs et al., 2021). Although explorations into the pathogenesis of asthma are increasing, the underlying molecular and cellular mechanisms of asthma remain indistinct, and existing targeted therapy strategies are still limited and ineffective. Therefore, it is necessary to explore the mechanisms of asthma and identify new therapeutic targets for asthma treatment.