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Regulation of endogenous retroviruses in murine embryonic stem cells and early embryos
Xinyi Lu*
State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300350, China
*Correspondence to:Xinyi Lu ,
J Mol Cell Biol, Volume 15, Issue 8, August 2023, mjad052,
Keyword: endogenous retrovirus, embryonic stem cell, epigenetic regulation, transcriptional regulation, post-transcriptional regulation

Endogenous retroviruses (ERVs) are important components of transposable elements that constitute ∼40% of the mouse genome. ERVs exhibit dynamic expression patterns during early embryonic development and are engaged in numerous biological processes. Therefore, ERV expression must be closely monitored in cells. Most studies have focused on the regulation of ERV expression in mouse embryonic stem cells (ESCs) and during early embryonic development. This review touches on the classification, expression, and functions of ERVs in mouse ESCs and early embryos and mainly discusses ERV modulation strategies from the perspectives of transcription, epigenetic modification, nucleosome/chromatin assembly, and post-transcriptional control.