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Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila Free
Xiangdong Lv 1,† , Hao Chen 1,† , Shuo Zhang 1 , Zhao Zhang 1 , Chenyu Pan 1 , Yuanxin Xia 1 , Jialin Fan 1 , Wenqing Wu 1 , Yi Lu 1 , Lei Zhang 1,2 , Hailong Wu 1,* , and Yun Zhao 1,2,*
1 State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China
2 School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
These two authors contributed equally to this work. *Correspondence to:Yun Zhao, E-mail: yunzhao@sibcb.ac.cn; Hailong Wu, E-mail: wu.hailong@sibcb.ac.cn
J Mol Cell Biol, Volume 10, Issue 5, October 2018, Pages 475-478  https://doi.org/10.1093/jmcb/mjy009

Dear Editor,

The highly conserved polycomb group (PcG) proteins were initially identified in Drosophila to maintain repression state of the transcription of homeotic genes, which is critical for animal development control (Sawarkar and Paro, 2010). Polycomb repressive complexes 1 (PRC1) and 2 (PRC2) are two important multi-protein complexes of PcG proteins regulating target gene expression. In Drosophila, PRC2 is composed of Enhancer of zeste (E(z)), Suppressor of zeste 12 (Su(z)12), Extra sex combs (esc), and Chromatin assembly factor 1 subunit (Caf1). E(z) is the catalytic subunit for H3K27me2/3, while both Su(z)12 and Esc are...