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A parallel mechanism underlying frizzle in domestic chickens Free
Xing Guo 1,† , Yan-Qing Li 2,† , Ming-Shan Wang 1,† , Zhi-Bin Wang 2,† , Quan Zhang 2 , Yong Shao 1 , Run-Shen Jiang 3 , Sheng Wang 4 , Chen-Dong Ma 3 , Robert W. Murphy 1,5 , Guang-Qin Wang 6 , Jing Dong 2 , Li Zhang 2 , Dong-Dong Wu 1,7,8,* , Bing-Wang Du 2,* , Min-Sheng Peng 1,7,* , and Ya-Ping Zhang 1,7,8,9,*
1 State Key Laboratory of Genetic Resources and Evolution and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
2 College of Agricultural, Guangdong Ocean University, Zhanjiang 524088, China
3 College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036,China
4 Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture of China, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
5 Centre for Biodiversity and Conservation Biology, Royal Ontario Museum, Toronto, M5S2C6, Canada
6 Jinsheng Animal Husbandry Technology Co.Ltd, Zhanjiang 524025, China
7 Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China
8 Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China
9 State Key Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, China
These authors contributed equally to this work.
*Correspondence to:*Correspondence to: Dong-Dong Wu, E-mail: wudongdong@mail.kiz.ac.cn; Bing-Wang Du, E-mail: dudu903@163.com; Min-Sheng Peng, E-mail: pengminsheng@mail.kiz.ac.cn; Ya-Ping Zhang, E-mail: zhangyp@mail.kiz.ac.cn
J Mol Cell Biol, Volume 10, Issue 6, December 2018, Pages 589-591  https://doi.org/10.1093/jmcb/mjy037

The feather, a highly keratinized tissue with variations in the shape, distribution, pigmentation, and structure, is an attractive topic in developmental and evolutionary biology (Boer et al., 2017). One phenotype noted by Darwin (Darwin, 1868), frizzle, consists of feather rachis and barbs curling outwards. It was previously reported that a 69-bp deletion in KRT6A (formerly named as KRT75 in the original paper; see Supplementary Materials and methods for details) was responsible for frizzle in chicken (Ng et al., 2012). Nevertheless, a recent screening of KRT6A in the Qilin chicken, a frizzle breed from Southern China (Supplementary Materials and methods, and Figures S1 and S2), failed to detect the 69-bp deletion (Tao et al., 2015). This raises a possibility that there is an independent genetic mechanism determining frizzle in Qilin chicken. To dissect this issue, we adopt a comparative population genomic strategy to investigate the genetic basis underlying frizzle in Qilin chickens. This strategy has been shown efficient in studying the phenotypic evolution in chicken (Wang et al., 2016, 2017).