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Intricacies in the cross talk between metabolic enzymes, RNA, and protein translation
Yuan Lv 1,2,3,4,5, Muqddas Tariq 1,2,3,4,5, Xiangpeng Guo 1,2,3,4, Shahzina Kanwal 1,2,3,4,* , and Miguel A. Esteban 1,2,3,4,6
1 Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, Guangzhou 511436, China
2 Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
3 Laboratory of RNA, Chromatin, and Human Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
4 Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, China
5 University of Chinese Academy of Sciences, Beijing 100049, China
6 Institute for Stem Cells and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
*Correspondence to:Shahzina Kanwal, E-mail: shahzina@gibh.ac.cn
J Mol Cell Biol, Volume 11, Issue 10, October 2019, Pages 813-815  https://doi.org/10.1093/jmcb/mjz089

The development of techniques allowing the systematic capture of the RNA-bound proteome has yielded many surprises. Among these, metabolic enzymes have been frequently detected as RNA-binding proteins (RBPs) by different profiling methodologies in various cell types (Hentze et al., 2018). Compared to previous—more simplistic—views, it is now known that cellular metabolism (not only limited to the tricarboxylic acid, TCA, cycle) is compartmentalized. In fact, metabolic enzymes translocate to the nucleus and are enriched at actively transcribed loci, where they sustain