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Volume 9, Issue 5, October 2017

Editorial

New ways to maintain or disrupt metabolic homeostasis Free
Jiarui Wu
J Mol Cell Biol, Volume 9, Issue 5, October 2017, 351-351, https://doi.org/10.1093/jmcb/mjx049
Abstract | Full Text 

Review

Krüppel-like factors and vascular wall homeostasis Free
Yanbo Fan, Haocheng Lu, Wenying Liang, Wenting Hu, Jifeng Zhang, and Y. Eugene Chen
J Mol Cell Biol, Volume 9, Issue 5, October 2017, 352-363, https://doi.org/10.1093/jmcb/mjx037
Abstract | Full Text 

Articles

Cold adaptation in pigs depends on UCP3 in beige adipocytes Free
Jun Lin, Chunwei Cao, Cong Tao, Rongcai Ye, Meng Dong, Qiantao Zheng, Chao Wang, Xiaoxiao Jiang, Guosong Qin, Changguo Yan, Kui Li, John R. Speakman, Yanfang Wang, Wanzhu Jin, and Jianguo Zhao
J Mol Cell Biol, Volume 9, Issue 5, October 2017, 364-375, https://doi.org/10.1093/jmcb/mjx018
Abstract | Full Text 
Whole-exome sequencing identifies a novel INS mutation causative of maturity-onset diabetes of the young 10 Free
Jing Yan, Feng Jiang, Rong Zhang, Tongfu Xu, Zhou Zhou, Wei Ren, Danfeng Peng, Yong Liu, Cheng Hu, and Weiping Jia
J Mol Cell Biol, Volume 9, Issue 5, October 2017, 376-383, https://doi.org/10.1093/jmcb/mjx039
Abstract | Full Text 
Pak1 mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression Free
Kejing Zeng, Lili Tian, Adam Sirek, Weijuan Shao, Ling Liu, Yu-Ting Chiang, Jonathan Chernoff, Dominic S. Ng, Jianping Weng, and Tianru Jin
J Mol Cell Biol, Volume 9, Issue 5, October 2017, 384-394, https://doi.org/10.1093/jmcb/mjx031
Abstract | Full Text 
Determination of glucose deficiency-induced cell death by mitochondrial ATP generation-driven proton homeostasis Free
Yanfen Cui, Yuanyuan Wang, Miao Liu, Li Qiu, Pan Xing, Xin Wang, Guoguang Ying, and Binghui Li
J Mol Cell Biol, Volume 9, Issue 5, October 2017, 395-408, https://doi.org/10.1093/jmcb/mjx011
Abstract | Full Text 
The steady-state level of CDK4 protein is regulated by antagonistic actions between PAQR4 and SKP2 and involved in tumorigenesis Free
Lin Wang, Rui Zhang, Xue You, Huanhuan Zhang, Siying Wei, Tingting Cheng, Qianqian Cao, Zhenzhen Wang, and Yan Chen
J Mol Cell Biol, Volume 9, Issue 5, October 2017, 409-421, https://doi.org/10.1093/jmcb/mjx028
Abstract | Full Text 
Myeloid adrenergic signaling via CaMKII forms a feedforward loop of catecholamine biosynthesis Free
Yan Luo, Bilian Liu, Xin Yang, Xiaoxiao Ma, Xing Zhang, Denis E. Bragin, Xuexian O. Yang, Wendong Huang, and Meilian Liu
J Mol Cell Biol, Volume 9, Issue 5, October 2017, 422-434,
Abstract | Full Text 

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Cover: In ß cells, the single chain precursor preproinsulin is cleaved of the signal peptide to produce proinsulin across the ER membrane. Wild-type proinsulin is then folded and delivered to the Golgi apparatus to form mature insulin, which is stored in secretory granules to be secreted (left). In contrast, the p.Ala2Thr mutation located at the signal peptide in INS gene results in an improperly cleaved proinslin, which is unfolded and retained in the ER to trigger ER stress, leading to impaired ß cell secretion function and resultant hyperglycemia (right). This causative mutation p.Ala2Thr in INS is responsible for MODY10 in Chinese population. See pages 376–383 by Yan et al. for details.