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Volume 12, Issue 8, August 2020

Editorial

Modeling cellular polarity, plasticity, and disease disparity in 4D 
Xuebiao Yao
J Mol Cell Biol, Volume 12, Issue 8, August 2020, 559-561, https://doi.org/10.1093/jmcb/mjaa039
Abstract | Full Text 

Perspective

Intestinal organoids as tools for enriching and studying specific and rare cell types: advances and future directions
Kim E. Boonekamp, Talya L. Dayton, Hans Clevers
J Mol Cell Biol, Volume 12, Issue 8, August 2020, 562-568, https://doi.org/10.1093/jmcb/mjaa034
Abstract | Full Text 

Reviews

Organoid technology for tissue engineering
Juan He, Xiaoyu Zhang, Xinyi Xia, Ming Han, Fei Li, Chunfeng Li, Yunguang Li, Dong Gao
J Mol Cell Biol, Volume 12, Issue 8, August 2020, 569-579, https://doi.org/10.1093/jmcb/mjaa012
Abstract | Full Text 
Modeling endodermal organ development and diseases using human pluripotent stem cell-derived organoids
Fong Cheng Pan, Todd Evans, Shuibing Chen
J Mol Cell Biol, Volume 12, Issue 8, August 2020, 580-592, https://doi.org/10.1093/jmcb/mjaa031
Abstract | Full Text 
Tumor organoids to study gastroesophageal cancer: a primer
Ramon U. Jin, Jason C. Mills
J Mol Cell Biol, Volume 12, Issue 8, August 2020, 593-606, https://doi.org/10.1093/jmcb/mjaa035
Abstract | Full Text 
Progress in human liver organoids
Lulu Sun, Lijian Hui
J Mol Cell Biol, Volume 12, Issue 8, August 2020, 607-617, https://doi.org/10.1093/jmcb/mjaa013
Abstract | Full Text 

Articles

Generation of liver bipotential organoids with a small-molecule cocktail 
Xin Wang, Chao Ni, Ning Jiang, Jinsong Wei, Jianqing Liang, Bing Zhao, Xinhua Lin
J Mol Cell Biol, Volume 12, Issue 8, August 2020, 618-629, https://doi.org/10.1093/jmcb/mjaa010
Abstract | Full Text 
Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening
Yuhong Du, Xingnan Li, Qiankun Niu, Xiulei Mo, Min Qui, Tingxuan Ma, Calvin J. Kuo, Haian Fu
J Mol Cell Biol, Volume 12, Issue 8, August 2020, 630-643, https://doi.org/10.1093/jmcb/mjaa036
Abstract | Full Text 
In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease
Tijmen H. Booij, Wouter N. Leonhard, Hester Bange, Kuan Yan, Michiel Fokkelman, Anna J. Plugge, Kimberley A.M. Veraar, Johannes G. Dauwerse, Gerard J.P. van Westen, Bob van de Water, Leo S. Price, Dorien J.M. Peters
J Mol Cell Biol, Volume 12, Issue 8, August 2020, 644-653, https://doi.org/10.1093/jmcb/mjz029
Abstract | Full Text 
Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly
Xu Liu, Leilei Xu, Junying Li, Phil Y. Yao, Wanjuan Wang, Hazrat Ismail, Haowei Wang, Bryce Liao, Zhihong Yang, Tarsha Ward, Ke Ruan, Jianchun Zhang, Quan Wu, Ping He, Xia Ding, Dongmei Wang, Chuanhai Fu, Zhen Dou, Feng Yan, Wenwen Wang, Xing Liu, Xuebiao Yao
J Mol Cell Biol, Volume 12, Issue 8, August 2020, 654-665, https://doi.org/10.1093/jmcb/mjz051
Abstract | Full Text 

Highlight

Organoid-based chemical approach to dissect the mechanism controlling cellular dynamics
Lauretta A. Lacko, Shuibing Chen
J Mol Cell Biol, Volume 12, Issue 8, August 2020, 666-667, https://doi.org/10.1093/jmcb/mjz100
Abstract | Full Text 

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Cover: The cover image depicts the culturing of human colon organoids with extracellular matrix to support 3D architecture in high-density plates, which enables the use of such a physiologically relevant model system in the ultra-high-throughput format for accelerated biological research and drug discovery. See pages 630-643 by Du et al. for details.