Journal of Molecular Cell Biology

Articles


Chemical approach to generating long-term self-renewing pMN progenitors from human embryonic stem cells Guan-Yu Zhang, Zhu-Man Lv, Hao-Xin Ma, Yu Chen, Yuan Yuan, Ping-Xin Sun, Yu-Qi Feng, Ya-Wen Li, Wen-Jie Lu, Yu-Dong Yang, Cheng Yang, Xin-Lu Yu, Chao Wang, Shu-Long Liang, Ming-Liang Zhang, Hui-Liang Li, Wen-Lin Li J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab076, https://doi.org/10.1093/jmcb/mjab076 Abstract \| Full Text

Chemical approach to generating long-term self-renewing pMN progenitors from human embryonic stem cells

Guan-Yu Zhang, Zhu-Man Lv, Hao-Xin Ma, Yu Chen, Yuan Yuan, Ping-Xin Sun, Yu-Qi Feng, Ya-Wen Li, Wen-Jie Lu, Yu-Dong Yang, Cheng Yang, Xin-Lu Yu, Chao Wang, Shu-Long Liang, Ming-Liang Zhang, Hui-Liang Li, Wen-Lin Li

J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab076, https://doi.org/10.1093/jmcb/mjab076

Abstract | Full Text


Cancer-derived C-terminus-extended p53 mutation confers dominant-negative effect on its wild-type counterpart Shibo Huang, Bo Cao, Jieqiong Wang, Yiwei Zhang, Elisa Ledet, Oliver Sartor, Yuqin Xiong, Shelya X. Zeng, Hua Lu J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab078, https://doi.org/10.1093/jmcb/mjab078 Abstract \| Full Text

Cancer-derived C-terminus-extended p53 mutation confers dominant-negative effect on its wild-type counterpart

Shibo Huang, Bo Cao, Jieqiong Wang, Yiwei Zhang, Elisa Ledet, Oliver Sartor, Yuqin Xiong, Shelya X. Zeng, Hua Lu

J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab078, https://doi.org/10.1093/jmcb/mjab078

Abstract | Full Text


LRRK2 regulates actin assembly for spindle migration and mitochondrial function in mouse oocyte meiosis Zhen-Nan Pan, Jing-Cai Liu, Jia-Qian Ju, Yue Wang, Shao-Chen Sun J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab079, https://doi.org/10.1093/jmcb/mjab079 Abstract \| Full Text

LRRK2 regulates actin assembly for spindle migration and mitochondrial function in mouse oocyte meiosis

Zhen-Nan Pan, Jing-Cai Liu, Jia-Qian Ju, Yue Wang, Shao-Chen Sun

J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab079, https://doi.org/10.1093/jmcb/mjab079

Abstract | Full Text


Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression Yuwei Li, Chencheng Yang, Huishan Wang, Ling Zhao, Qinghua Kong, Yu Cang, Shuhua Zhao, Longbao Lv, Yan Li, Bingyu Mao, Pengcheng Ma J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab082, https://doi.org/10.1093/jmcb/mjab082 Abstract \| Full Text

Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression

Yuwei Li, Chencheng Yang, Huishan Wang, Ling Zhao, Qinghua Kong, Yu Cang, Shuhua Zhao, Longbao Lv, Yan Li, Bingyu Mao, Pengcheng Ma

J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab082, https://doi.org/10.1093/jmcb/mjab082

Abstract | Full Text


‘C-type’ closed state and gating mechanisms of K2P channels revealed by conformational changes of the TREK-1 channel Qiansen Zhang, Jie Fu, Shaoying Zhang, Peipei Guo, Shĳie Liu, Juwen Shen, Jiangtao Guo, Huaiyu Yang J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjac002, https://doi.org/10.1093/jmcb/mjac002 Abstract \| Full Text

‘C-type’ closed state and gating mechanisms of K2P channels revealed by conformational changes of the TREK-1 channel

Qiansen Zhang, Jie Fu, Shaoying Zhang, Peipei Guo, Shĳie Liu, Juwen Shen, Jiangtao Guo, Huaiyu Yang

J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjac002, https://doi.org/10.1093/jmcb/mjac002

Abstract | Full Text

Letter to the Editor


NuMA forms condensates through phase separation to drive spindle pole assembly Huixian Ma, Feifei Qi, Li Ji, Songbo Xie, Jie Ran, Min Liu, Jinmin Gao, Jun Zhou J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab081, https://doi.org/10.1093/jmcb/mjab081 Abstract \| Full Text

NuMA forms condensates through phase separation to drive spindle pole assembly

Huixian Ma, Feifei Qi, Li Ji, Songbo Xie, Jie Ran, Min Liu, Jinmin Gao, Jun Zhou

J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab081, https://doi.org/10.1093/jmcb/mjab081

Abstract | Full Text

Research Advance


Comments on ‘An airway organoid-based screen identifies a role for the HIF1α‒glycolysis axis in SARS-CoV-2 infection’ Xiaohua Duan, Hui Wang, David D. Ho, Robert E. Schwartz, Todd Evans, Shuibing Chen J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab075, https://doi.org/10.1093/jmcb/mjab075 Abstract \| Full Text

Comments on ‘An airway organoid-based screen identifies a role for the HIF1α‒glycolysis axis in SARS-CoV-2 infection’

Xiaohua Duan, Hui Wang, David D. Ho, Robert E. Schwartz, Todd Evans, Shuibing Chen

J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab075, https://doi.org/10.1093/jmcb/mjab075

Abstract | Full Text


ADP-riboxanation: a new pyroptosis evasion strategy Heyu Li, Fangfang Zhou, Long Zhang J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab077, https://doi.org/10.1093/jmcb/mjab077 Abstract \| Full Text

ADP-riboxanation: a new pyroptosis evasion strategy

Heyu Li, Fangfang Zhou, Long Zhang

J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab077, https://doi.org/10.1093/jmcb/mjab077

Abstract | Full Text


Chemokine CCL1 as a therapeutic target for pulmonary fibrosis: comments on ‘The chemokine CCL1 triggers an AMFR‒SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis’ Shanshan Liu, Chang Liu, Zhuowei Hu, Yang Xiao J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab080, https://doi.org/10.1093/jmcb/mjab080 Abstract \| Full Text

Chemokine CCL1 as a therapeutic target for pulmonary fibrosis: comments on ‘The chemokine CCL1 triggers an AMFR‒SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis’

Shanshan Liu, Chang Liu, Zhuowei Hu, Yang Xiao

J Mol Cell Biol, Volume 14, Issue 1, January 2022, mjab080, https://doi.org/10.1093/jmcb/mjab080

Abstract | Full Text

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Cover: MD simulations on a K2P channel reveal a novel ‘C-type’ closed conformation by pulling M4 helix to allosterically modulate fi lter gating. The ‘seesaw’ movements of M4 helix induce rearrangements of networks within the fi lter region. The novel gating mechanisms help to elucidate allosteric mechanisms of ligand activation and gain‐of‐function mutations, which further support the understanding of closed state. The image was contributed by Qiansen Zhang and Huaiyu Yang. See mjac002 by Zhang et al. for details.