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Volume 14, Issue 4, April 2022

Research Highlights

A sugary addition to the urea cycle
Chad Slawson
J Mol Cell Biol, Volume 14, Issue 4, April 2022, mjac027, https://doi.org/10.1093/jmcb/mjac027
Abstract | Full Text 

Reviews

The molecular regulation of autophagy in antimicrobial immunity
Chuan Qin, Yalan Lu, Lin Bai, Kewei Wang
J Mol Cell Biol, Volume 14, Issue 4, April 2022, mjac015, https://doi.org/10.1093/jmcb/mjac015
Abstract | Full Text 
The pleiotropic roles of cGAS–STING signaling in the tumor microenvironment
Jun Li, Samuel F. Bakhoum
J Mol Cell Biol, Volume 14, Issue 4, April 2022, mjac019, https://doi.org/10.1093/jmcb/mjac019
Abstract | Full Text 
Detecting SARS-CoV-2 neutralizing immunity: highlighting the potential of split nanoluciferase technology
Sundararaj Stanleyraj Jeremiah, Kei Miyakawa, Akihide Ryo
J Mol Cell Biol, Volume 14, Issue 4, April 2022, mjac023, https://doi.org/10.1093/jmcb/mjac023
Abstract | Full Text 

Articles

Deacetylation of MTHFD2 by SIRT4 senses stress signal to inhibit cancer cell growth by remodeling folate metabolism
Fan Zhang, Di Wang, Jintao Li, Ying Su, Suling Liu, Qun-Ying Lei, Miao Yin
J Mol Cell Biol, Volume 14, Issue 4, April 2022, mjac020, https://doi.org/10.1093/jmcb/mjac020
Abstract | Full Text 
SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients
Marjorie C. Pontelli, Ítalo A. Castro, Ronaldo B. Martins, Leonardo La Serra, Flávio P. Veras, Daniele C. Nascimento, Camila M. Silva, Ricardo S. Cardoso, Roberta Rosales, Rogério Gomes, Thais M. Lima, Juliano P. Souza, Brenda C. Vitti, Diego B. Caetité, Mikhael H. F. de Lima, Spencer D. Stumpf, Cassandra E. Thompson, Louis-Marie Bloyet, Juliana E. Toller-Kawahisa, Marcela C. Giannini, Letícia P. Bonjorno, Maria I. F. Lopes, Sabrina S. Batah, Li Siyuan, Rodrigo Luppino-Assad, Sergio C. L. Almeida, Fabiola R. Oliveira, Maíra N. Benatti, Lorena L. F. Pontes, Rodrigo C. Santana, Fernando C. Vilar, Maria Auxiliadora-Martins, Pei-Yong Shi, Thiago M. Cunha, Rodrigo T. Calado, José C. Alves-Filho, Dario S. Zamboni, Alexandre T. Fabro, Paulo Louzada-Junior, Rene D. R. Oliveira, Sean P. J. Whelan, Fernando Q. Cunha, Eurico Arruda
J Mol Cell Biol, Volume 14, Issue 4, April 2022, mjac021, https://doi.org/10.1093/jmcb/mjac021
Abstract | Full Text 

Letters to the Editor

Enhancing prime editing efficiency by modified pegRNA with RNA G-quadruplexes
Xiangyang Li, Xin Wang, Wenjun Sun, Shisheng Huang, Mingtian Zhong, Yuan Yao, Quanjiang Ji, Xingxu Huang
J Mol Cell Biol, Volume 14, Issue 4, April 2022, mjac022, https://doi.org/10.1093/jmcb/mjac022
Abstract | Full Text 
Supplementation of nicotinamide mononucleotide improves the quality of postovulatory aged porcine oocytes
Yilong Miao, Zhaokang Cui, Xiaotong Zhu, Qian Gao, Bo Xiong
J Mol Cell Biol, Volume 14, Issue 4, April 2022, mjac025, https://doi.org/10.1093/jmcb/mjac025
Abstract | Full Text 

Research Advance

Malic enzyme 2 as a therapeutic target for cancer: comments on ‘Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate’
Zhenxi Zhang, Wenjing Du
J Mol Cell Biol, Volume 14, Issue 4, April 2022, mjac024, https://doi.org/10.1093/jmcb/mjac024
Abstract | Full Text 
Heat shock factor 1 in fat biology: comments on ‘Local hyperthermia therapy induces browning of white fat and treats obesity’ 
Lingyan Xu, Yu Li, Yankang Zhang, Ting Zhang, Dongmei Wang, Xinran Ma
J Mol Cell Biol, Volume 14, Issue 4, April 2022, mjac026, https://doi.org/10.1093/jmcb/mjac026
Abstract | Full Text 

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Cover: Postovulatory aging is known to compromise the oocyte quality as well as subsequent embryonic developmental potential in many different animal models, and thus becomes one of the most intractable issues that limit the outcome of human assisted reproductive technology. The recent fi ndings demonstrate that supplementation of nicotinamide mononucleotide (NMN, a key NAD+ intermediate for its biosynthesis) improves the quality of postovulatory aged porcine oocytes by strengthening the mitochondrial function. See mjac025 by Miao et al. for details.