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Proteome-wide data analysis reveals tissue-specific network associated with SARS-CoV-2 infection 
Li Feng1,2,† , Yuan-Yuan Yin1,2,† , Cong-Hui Liu1 , Ke-Ren Xu1,2 , Qing-Run Li1 , Jia-Rui Wu1,3,* , Rong Zeng1,3,*
1CAS Key Laboratory of Systems Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Mollecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China
2College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
3CAS Key Laboratory of Systems Biology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou 310024, China
These authors contributed equally to this work.
*Correspondence to:Jia-Rui Wu , Email:wujr@sibs.ac.cn Rong Zeng , Email:zr@sibcb.ac.cn
J Mol Cell Biol, Volume 12, Issue 12, December 2020, Pages 946-957  https://doi.org/10.1093/jmcb/mjaa033
Keyword: SARS-CoV-2, proteome-wide, tissue-specific

For patients with COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the damages to multiple organs have been clinically observed. Since most of current investigations for virus–host interaction are based on cell level, there is an urgent demand to probe tissue-specific features associated with SARS-CoV-2 infection. Based on collected proteomic datasets from human lung, colon, kidney, liver, and heart, we constructed a virus-receptor network, a virus-interaction network, and a virus-perturbation network. In the tissue-specific networks associated with virus–host crosstalk, both common and different key hubs are revealed in diverse tissues. Ubiquitous hubs in multiple tissues such as BRD4 and RIPK1 would be promising drug targets to rescue multi-organ injury and deal with inflammation. Certain tissue-unique hubs such as REEP5 might mediate specific olfactory dysfunction. The present analysis implies that SARS-CoV-2 could affect multi-targets in diverse host tissues, and the treatment of COVID-19 would be a complex task.