< Previous         Next >  
The role of O-GlcNAcylation in innate immunity and inflammation
Yongqiang Wang1,† , Xiuwu Fang1,† , Shuai Wang1,† , Bin Wang2,† , Feng Chu1,† , Zhixin Tian1 , Long Zhang2,* , Fangfang Zhou1,*
1Institutes of Biology and Medical Science, Soochow University, Suzhou 215123, China
2MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China
These authors contributed equally to this work
*Correspondence to:Long Zhang , Fangfang Zhou ,
J Mol Cell Biol, Volume 14, Issue 9, September 2022, mjac065,
Keyword: innate immunity, inflammation, O-GlcNAcylation, cancer

O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is a highly dynamic and widespread post-translational modification (PTM) that regulates the activity, subcellular localization, and stability of target proteins. O-GlcNAcylation is a reversible PTM controlled by two cycling enzymes: O-linked N-acetylglucosamine transferase and O-GlcNAcase. Emerging evidence indicates that O-GlcNAcylation plays critical roles in innate immunity, inflammatory signaling, and cancer development. O-GlcNAcylation usually occurs on serine/threonine residues, where it interacts with other PTMs, such as phosphorylation. Thus, it likely has a broad regulatory scope. This review discusses the recent research advances regarding the regulatory roles of O-GlcNAcylation in innate immunity and inflammation. A more comprehensive understanding of O-GlcNAcylation could help to optimize therapeutic strategies regarding inflammatory diseases and cancer.