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Legionella pneumophila-mediated host posttranslational modifications
Yi Yang1,† , Ligang Mei1,† , Jing Chen1 , Xiaorong Chen1 , Zhuolin Wang1 , Lu Liu1,* , Aimin Yang1,*
1School of Life Sciences, Chongqing University, Chongqing 401331, China
These authors contributed equally to this work
*Correspondence to:Aimin Yang , Lu Liu ,
J Mol Cell Biol, Volume 15, Issue 5, May 2023, mjad032,
Keyword: Legionella pneumophila, bacterial effector, posttranslational modification, host–pathogen interaction, Legionella-containing vacuole, pathogenesis, host defense system

Legionella pneumophila is a Gram-negative bacterium ubiquitously present in freshwater environments and causes a serious type of pneumonia called Legionnaires’ disease. During infections, L. pneumophila releases over 300 effector proteins into host cells through an Icm/Dot type IV secretion system to manipulate the host defense system for survival within the host. Notably, certain effector proteins mediate posttranslational modifications (PTMs), serving as useful approaches exploited by L. pneumophila to modify host proteins. Some effectors catalyze the addition of host protein PTMs, while others mediate the removal of PTMs from host proteins. In this review, we summarize L. pneumophila effector-mediated PTMs of host proteins, including phosphorylation, ubiquitination, glycosylation, AMPylation, phosphocholination, methylation, and ADP-ribosylation, as well as dephosphorylation, deubiquitination, deAMPylation, deADP-ribosylation, dephosphocholination, and delipidation. We describe their molecular mechanisms and biological functions in the regulation of bacterial growth and Legionella-containing vacuole biosynthesis and in the disruption of host immune and defense machinery.