1Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology, and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100871, China 2PKU-Nanjing Institute of Translational Medicine, Nanjing 211800, China †These authors contributed equally to this work *Correspondence to:Jing-Wei Xiong , Email:jingwei_xiong@pku.edu.cn