1MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China 2Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Hefei 230027, China 3Keck Center for Organoid Plasticity, Atlanta, GA 30310, USA 4Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China 5Department of Gastroenterology, Anhui University of Chinese Medicine, Hefei 230038, China 6Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710033, China *Correspondence to:Xing Liu , Email:xing1017@ustc.edu.cn Xuebiao Yao , Email:yaoxb@ustc.edu.cn