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New players critical for breast cancer Free
Hua Lu
Department of Biochemistry & Molecular Biology and Tulane Cancer Center, Tulane
University School of Medicine, New Orleans, LA 70112, USA
E-mail: hlu2@tulane.edu *Correspondence to:
J Mol Cell Biol, Volume 10, Issue 4, August 2018, Pages 271-272  https://doi.org/10.1093/jmcb/mjy046

Breast cancer (BC) is the most malignant cancer and the second leading cause of deaths in women worldwide. It is typically classified into the following three subtypes: estrogen receptor (ER)/progesterone receptor (PR)-positive (luminal), human epidermal growth factor receptor 2 (HER2)-amplified, and ER/PR/HER2-triple negative BC (TNBC). Tremendous progress has been made to understand molecular mechanisms underlying BC development, progression, and metastasis, and to develop molecule-targeted therapies for clinical applications. Yet, some molecular details are still missing, and the mortality rate of patients with luminal B BC or TNBC still remains high. Hence, it is important to search for more previously unknown genes or molecules responsible for...