Volume 11, Issue 4, April 2019

Editorial

p53: updates on mechanisms, biology and therapy (II) Free
David P. Lane, Chandra S. Verma
J Mol Cell Biol, Volume 11, Issue 4, April 2019, Pages 265-266, https://doi.org/10.1093/jmcb/mjz018
Abstract | Full Text 

Reviews

Mutant p53 in colon cancer
Mizuho Nakayama and Masanobu Oshima
J Mol Cell Biol, Volume 11, Issue 4, April 2019, Pages 267-276, https://doi.org/10.1093/jmcb/mjy075
Abstract | Full Text 
It takes a team: a gain-of-function story of p53-R249S
Huai Wang , Peng Liao, Shelya X. Zeng, and Hua Lu
J Mol Cell Biol, Volume 11, Issue 4, April 2019, Pages 277-283, https://doi.org/10.1093/jmcb/mjy086
Abstract | Full Text 
Tumor suppressor p53 and metabolism
Juan Liu, Cen Zhang, Wenwei Hu , and Zhaohui Feng
J Mol Cell Biol, Volume 11, Issue 4, April 2019, Pages 284-292, https://doi.org/10.1093/jmcb/mjy070
Abstract | Full Text 
Mutant p53 in cancer therapy—the barrier or the path
Xiang Zhou , Qian Hao , and Hua Lu
J Mol Cell Biol, Volume 11, Issue 4, April 2019, Pages 293-305, https://doi.org/10.1093/jmcb/mjy072
Abstract | Full Text 
Roles of computational modelling in understanding p53 structure, biology, and its therapeutic targeting
Yaw Sing Tan , Yasmina Mhoumadi , and Chandra S. Verma
J Mol Cell Biol, Volume 11, Issue 4, April 2019, Pages 306-316, https://doi.org/10.1093/jmcb/mjz009
Abstract | Full Text 
Understanding p53 functions through p53 antibodies
Kanaga Sabapathy and David P. Lane
J Mol Cell Biol, Volume 11, Issue 4, April 2019, Pages 317-329, https://doi.org/10.1093/jmcb/mjz010
Abstract | Full Text 
p53 as a hub in cellular redox regulation and therapeutic target in cancer Free
Sofi E. Eriksson, Sophia Ceder, Vladimir J.N. Bykov, and Klas G. Wiman
J Mol Cell Biol, Volume 11, Issue 4, April 2019, Pages 330-341, https://doi.org/10.1093/jmcb/mjz005
Abstract | Full Text 
Cover: Thiol-directed electrophilic attack disrupts the cellular antioxidant system and promotes mutant p53 refolding, which restores p53 tumor suppressor activity. The dual targeting of mutant p53 and redox homeostasis may allow more efficient treatment of cancer. See pages 330–341 by Eriksson et al. for details.