Volume 13, Issue 1, January 2021

Highlight

Reviews

The molecular mechanisms of MLKL-dependent and MLKL-independent necrosis
Lu Li, An Tong, Qiangsheng Zhang, Yuquan Wei, Xiawei Wei
J Mol Cell Biol, Volume 13, Issue 1, January 2021, Pages 3-14, https://doi.org/10.1093/jmcb/mjaa055
Abstract | Full Text 
Role and therapeutic potential of liquid–liquid phase separation in amyotrophic lateral sclerosis
Donya Pakravan, Gabriele Orlando, Vale´rie Bercier, Ludo Van Den Bosch
J Mol Cell Biol, Volume 13, Issue 1, January 2021, Pages 15-28, https://doi.org/10.1093/jmcb/mjaa049
Abstract | Full Text 

Articles

Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration
Xiangwen Peng, Kaa Seng Lai, Peilu She, Junsu Kang, Tingting Wang, Guobao Li, Yating Zhou, Jianjian Sun, Daqing Jin, Xiaolei Xu, Lujian Liao, Jiandong Liu, Ethan Lee, Kenneth D. Poss, Tao P. Zhong
J Mol Cell Biol, Volume 13, Issue 1, January 2021, Pages 41-58, https://doi.org/10.1093/jmcb/mjaa046
Abstract | Full Text 
A novel isoform of ATOH8 promotes the metastasis of breast cancer by regulating RhoC
Mengyao Xu, Shan Huang, Xiaoli Dong, Yanan Chen, Miao Li, Wen Shi, Guanwen Wang, Chongbiao Huang, Qiong Wang, Yanhua Liu, Peiqing Sun, Shuang Yang, Rong Xiang, Antao Chang
J Mol Cell Biol, Volume 13, Issue 1, January 2021, Pages 59-71, https://doi.org/10.1093/jmcb/mjaa050
Abstract | Full Text 

Letter to the Editor

Senescent bone marrow microenvironment promotes Nras-mutant leukemia
Peiqing Zhou, Chengxiang Xia, Tongjie Wang, Yong Dong, Qitong Weng, Xiaofei Liu, Yang Geng, Jinyong Wang, Juan Du
J Mol Cell Biol, Volume 13, Issue 1, January 2021, Pages 72-74, https://doi.org/10.1093/jmcb/mjaa062
Abstract | Full Text 

Application Note

Efficient replacement of long DNA fragments via non-homologous end joining at non-coding regions
Shanye Gu, Jia Li, Siyuan Li, Jianbin Cao, Jiwen Bu, Yonggang Ren, Wenjie Du, Zhecong Chen, Chufan Xu, Mingcang Wang, Lai Jiang, Cheng Huang, Jiulin Du
J Mol Cell Biol, Volume 13, Issue 1, January 2021, Pages 75-77, https://doi.org/10.1093/jmcb/mjaa051
Abstract | Full Text 
Cover: The cover shows that the lantern flickering on a boat gives signals to the city and two gates of the defensive wall open. During organelle remodeling, on the arrival of a boat (mitochondrion), flickering light from the lantern (permeability transition pore, PTP) gives strong signals to the city (nucleus), and two usually locked gates (H3K9me2 and H3K27me3) of the defensive wall respond and open immediately. Mitochondrial flicker, by short-term mPTP opening, acts as a retrograde signaling to specially open methylation gates of nucleus and facilitate somatic cell reprogramming process. See pages 747-751 by Liu et al. for details.